内脏脂肪指数与糖尿病患者新发肾病和视网膜病变的相关性：一项队列研究。
Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population.
机构信息
Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, Beijing, 100069, China.
Centre for Precision Health, Edith Cowan University, Perth, Australia.
出版信息
Cardiovasc Diabetol. 2022 Feb 24;21(1):32. doi: 10.1186/s12933-022-01464-1.
BACKGROUND
The association between visceral adiposity index (VAI) and diabetic complications has been reported in cross-sectional studies, while the effect of VAI on complication development remains unclear. This study aims to evaluate the longitudinal association of VAI and Chinese VAI (CVAI) with the incidence of diabetic nephropathy and retinopathy using a Chinese cohort.
METHODS
A total of 8 948 participants with type 2 diabetes from Beijing Health Management Cohort were enrolled during 2013-2014, and followed until December 31, 2019. Nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate; retinopathy was diagnosed using fundus photograph.
RESULTS
The mean (SD) age was 53.35 (14.66) years, and 6 154 (68.8%) were men. During a median follow-up of 4.82 years, 467 participants developed nephropathy and 90 participants developed retinopathy. One-SD increase in VAI and CVAI levels were significantly associated with an increased risk of nephropathy, and the adjusted hazard ratios (HR) were 1.127 (95% CI 1.050-1.210) and 1.165 (95% CI 1.003-1.353), respectively. On contrary, VAI and CVAI level were not associated with retinopathy after adjusting confounding factors.
CONCLUSION
VAI and CVAI are independently associated with the development of nephropathy, but not retinopathy in Chinese adults with diabetes.
背景
横断面研究报道内脏脂肪指数（VAI）与糖尿病并发症之间存在关联，而 VAI 对并发症发展的影响尚不清楚。本研究旨在使用中国队列评估 VAI 和中国 VAI（CVAI）与糖尿病肾病和视网膜病变发生的纵向关联。
方法
2013-2014 年期间，共纳入来自北京健康管理队列的 8948 名 2 型糖尿病患者，并随访至 2019 年 12 月 31 日。肾病通过尿白蛋白/肌酐比值和估计肾小球滤过率确定；视网膜病变通过眼底照片诊断。
结果
平均（SD）年龄为 53.35（14.66）岁，6154 人（68.8%）为男性。中位随访 4.82 年后，467 人发生肾病，90 人发生视网膜病变。VAI 和 CVAI 水平每增加 1 个标准差，肾病发病风险显著增加，调整后的危险比（HR）分别为 1.127（95%CI 1.050-1.210）和 1.165（95%CI 1.003-1.353）。相反，调整混杂因素后，VAI 和 CVAI 水平与视网膜病变无关。
结论
VAI 和 CVAI 与中国糖尿病成人的肾病发生独立相关，但与视网膜病变无关。
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