Department of Child Health Care, Luohu Maternal and Child Health Care Hospital, Shenzhen, Guangdong 518019, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Feb 15;24(2):182-185. doi: 10.7499/j.issn.1008-8830.2110036.
To study the efficacy of intermittent iron supplementation in children with mild iron-deficiency anemia.
A total of 147 children with mild iron-deficiency anemia were enrolled in this prospective study. They were divided into an intermittent iron supplementation group (=83) and a conventional iron supplementation group (=64). The levels of hemoglobin were measured before treatment and after 1 and 3 months of treatment. The treat response rate and the incidence rate of adverse drug reactions were compared between the two groups.
Both groups had a significant increase in the level of hemoglobin after iron supplementation (<0.05). After 1 month of treatment, the conventional iron supplementation group had a significantly higher treatment response rate than the intermittent iron supplementation group (61% vs 42%, <0.05). After 3 months of treatment, there was no significant difference in the treatment response between the two groups (86% vs 78%, >0.05). The incidence rate of adverse drug reactions in the conventional iron supplementation group was significantly higher than that in the intermittent iron supplementation group (25% vs 8%, <0.05).
For children with mild iron-deficiency anemia, although intermittent iron supplementation is inferior to conventional iron supplementation in the short-term efficacy, there is no significant difference in the long-term efficacy between the two methods, and compared with conventional iron supplementation, intermittent iron supplementation can reduce the incidence of adverse drug reactions, alleviate family financial burdens, and improve treatment compliance of children, thus holding promise for clinical application.
研究间歇性补铁治疗儿童轻度缺铁性贫血的疗效。
前瞻性研究共纳入 147 例轻度缺铁性贫血患儿，将其分为间歇性补铁组（n=83）和常规补铁组（n=64）。治疗前及治疗 1 个月和 3 个月后检测血红蛋白水平，比较两组的治疗应答率及药物不良反应发生率。
两组补铁后血红蛋白水平均显著升高（<0.05）。治疗 1 个月时，常规补铁组的治疗应答率显著高于间歇性补铁组（61% vs 42%，<0.05）。治疗 3 个月时，两组的治疗应答率无显著差异（86% vs 78%，>0.05）。常规补铁组药物不良反应发生率显著高于间歇性补铁组（25% vs 8%，<0.05）。
对于轻度缺铁性贫血患儿，虽然在短期疗效方面间歇性补铁不如常规补铁，但两种方法的长期疗效无显著差异，与常规补铁相比，间歇性补铁可降低药物不良反应发生率，减轻患儿家庭经济负担，提高患儿治疗依从性，具有一定的临床应用前景。
