Anderson W R, Rao K V
Ultrastruct Pathol. 1986;10(3):227-34. doi: 10.3109/01913128609032221.
This study describes the ultrastructural features of hemosiderosis occurring in five transplant recipients. Iron deposits in the form of homogeneous and heterogeneous siderosomes (iron-laden lysosomes) were found within the hepatocytes and macrophages in areas of fibrosis, and to a lesser degree within Kupffer cells and bile duct epithelium. Disruption of siderosomal membranes with extrusion of ferritin particles into the cytosol was demonstrated in these specimens and may be significant in the pathogenesis of hepatocellular injury.
本研究描述了5例移植受者发生的含铁血黄素沉着症的超微结构特征。在纤维化区域的肝细胞和巨噬细胞内发现了呈均匀和不均匀含铁小体（含铁溶酶体）形式的铁沉积，在库普弗细胞和胆管上皮细胞内的沉积程度较轻。在这些标本中证实了含铁小体膜的破裂以及铁蛋白颗粒向细胞质的挤出，这在肝细胞损伤的发病机制中可能具有重要意义。
