Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Cell Death Dis. 2022 Feb 24;13(2):182. doi: 10.1038/s41419-022-04628-9.
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality. As a form of programmed cell death (PCD), ferroptosis could be considered as a process of iron accumulation and enhanced lipid peroxidation. Recently, the fundamental roles of ferroptosis in AKI have attracted much attention. The network mechanism of ferroptosis in AKI and its roles in the AKI to chronic kidney disease (CKD) transition is complicated and multifactorial. Strategies targeting ferroptosis show great potential. Here, we review the research progress on ferroptosis and its participation in AKI. We hope that this work will provide clues for further studies of ferroptosis in AKI.
急性肾损伤（AKI）是一个具有高发病率和死亡率的重大公共卫生问题。作为一种程序性细胞死亡（PCD）形式，铁死亡可以被认为是铁积累和脂质过氧化增强的过程。最近，铁死亡在 AKI 中的基本作用引起了广泛关注。AKI 中铁死亡的网络机制及其在 AKI 向慢性肾脏病（CKD）转变中的作用是复杂的和多因素的。针对铁死亡的策略显示出巨大的潜力。在这里，我们综述了铁死亡及其在 AKI 中的作用的研究进展。我们希望这项工作将为 AKI 中铁死亡的进一步研究提供线索。
