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眼痛的脊髓上机制

Supraspinal Mechanisms Underlying Ocular Pain.

作者信息

Pondelis Nicholas J, Moulton Eric A

机构信息

Brain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

出版信息

Front Med (Lausanne). 2022 Feb 8;8:768649. doi: 10.3389/fmed.2021.768649. eCollection 2021.

DOI:10.3389/fmed.2021.768649
PMID:35211480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8862711/
Abstract

Supraspinal mechanisms of pain are increasingly understood to underlie neuropathic ocular conditions previously thought to be exclusively peripheral in nature. Isolating individual causes of centralized chronic conditions and differentiating them is critical to understanding the mechanisms underlying neuropathic eye pain and ultimately its treatment. Though few functional imaging studies have focused on the eye as an end-organ for the transduction of noxious stimuli, the brain networks related to pain processing have been extensively studied with functional neuroimaging over the past 20 years. This article will review the supraspinal mechanisms that underlie pain as they relate to the eye.

摘要

人们越来越认识到，疼痛的脊髓上机制是以前被认为完全是外周性的神经性眼部疾病的基础。分离出集中性慢性病的个体病因并加以区分，对于理解神经性眼痛的潜在机制以及最终的治疗方法至关重要。尽管很少有功能成像研究将眼睛作为有害刺激转导的终末器官进行关注，但在过去20年里，与疼痛处理相关的脑网络已通过功能神经成像得到了广泛研究。本文将综述与眼睛相关的疼痛脊髓上机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/474e752bf80e/fmed-08-768649-g0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/fd3dc48902d3/fmed-08-768649-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/6af8a54ac4e0/fmed-08-768649-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/e47e6573d85a/fmed-08-768649-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/d0e37295db90/fmed-08-768649-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/c746d32ddd77/fmed-08-768649-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/a10b418c8458/fmed-08-768649-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/f2a74dd2c05c/fmed-08-768649-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d550/8862711/474e752bf80e/fmed-08-768649-g0008.jpg

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Cereb Cortex. 2022 Jan 22;32(3):640-651. doi: 10.1093/cercor/bhab246.
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Neuropathic corneal pain and dry eye: a continuum of nociception.神经病理性角膜痛和干眼：痛觉传导的连续统一体。
Br J Ophthalmol. 2022 Aug;106(8):1039-1043. doi: 10.1136/bjophthalmol-2020-318469. Epub 2021 Apr 30.
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Neuroimage. 2021 Jul 15;235:118031. doi: 10.1016/j.neuroimage.2021.118031. Epub 2021 Apr 6.
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