Ren Ming-Yu, Li Jing, Li Rui-Miao, Wu Yi-Xiang, Han Rui-Juan, Zhang Chi
Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China.
Intensive Care Unit, Xingtai Third Hospital, Xingtai 054001, Hebei Province, China.
World J Clin Cases. 2022 Feb 16;10(5):1623-1629. doi: 10.12998/wjcc.v10.i5.1623.
Synovial sarcoma is a malignant mesenchymal neoplasm with variable epithelial differentiation. Most synovial sarcoma cases are reported in young adults and can arise in any body site. Notably, primary orbital synovial sarcoma is rare.
An 8-year-old east Asian girl with 1-month history of gradual painless proptosis and lacrimation of the right eye was admitted. The patient presented with painless proptosis, downward eyeball displacement, and upward movement disorders. According to clinical manifestations, imaging examinations and postoperative immunohistochemical examinations, the diagnosis was monophasic synovial sarcoma with calcification. The patient underwent anterior orbitotomy procedure for removal of the right orbital mass under general anesthesia. The diagnosis of monophasic synovial sarcoma with calcification was confirmed finally through histological and immunohistochemical exam. The follow-up period was 6 mo, and no recurrence was observed during this period.
Primary orbital monophasic synovial sarcoma with calcification is a rare sarcoma, and clinical manifestations and imaging results are not specific. The tumor may present similar features as a benign tumor. Comprehensive analysis of clinical, radiological, and pathological findings is critically important for making the right diagnosis. Conventional treatment approach for synovial sarcoma is surgical resection with adjuvant or neoadjuvant radiotherapy, which is highly effective for localized tumors.
滑膜肉瘤是一种具有可变上皮分化的恶性间叶性肿瘤。大多数滑膜肉瘤病例报告发生于年轻人，可出现在身体的任何部位。值得注意的是，原发性眼眶滑膜肉瘤很罕见。
一名8岁东亚女孩因右眼逐渐出现无痛性眼球突出和流泪1个月入院。患者表现为无痛性眼球突出、眼球向下移位和向上运动障碍。根据临床表现、影像学检查及术后免疫组织化学检查，诊断为伴有钙化的单相滑膜肉瘤。患者在全身麻醉下接受了前路眶切开术以切除右侧眼眶肿物。最终通过组织学和免疫组织化学检查确诊为伴有钙化的单相滑膜肉瘤。随访6个月，在此期间未观察到复发。
原发性眼眶伴有钙化的单相滑膜肉瘤是一种罕见的肉瘤，其临床表现和影像学结果不具有特异性。该肿瘤可能呈现出与良性肿瘤相似的特征。对临床、放射学和病理学检查结果进行综合分析对于做出正确诊断至关重要。滑膜肉瘤的传统治疗方法是手术切除并辅以辅助或新辅助放疗，这对局限性肿瘤非常有效。
