Agnati L F, Fuxe K, Eneroth P, Zini I, Härfstrand A, Grimaldi R, Zoli M
Acta Physiol Scand. 1986 Apr;126(4):525-31. doi: 10.1111/j.1748-1716.1986.tb07851.x.
By means of radioimmunoassay procedures, cholecystokinin-(CCK) and somatostatin-(SRIF) like immunoreactivity have been studied in the dorsal hippocampal formation and in the frontoparietal cortex of the male rat in insulin-induced hypoglycaemia, leading to an isoelectric EEG pattern. It has been demonstrated that severe hypoglycaemia of 40-min-duration produces a disappearance of SRIF but not of CCK-like immunoreactivity in both cortical regions. It was found that an i.v. injection of uridine but not of saline could significantly counteract the disappearance of SRIF-like immunoreactivity induced by severe hypoglycaemia in both cortical areas. Uridine did not by itself change plasma glucose levels. It is suggested that uridine may prevent release and/or increase synthesis of cortical SRIF peptides in severe hypoglycaemia, possibly due to an action on the metabolism (e.g. by enhancing the resynthesis of phosphatidyl inositol) within the tissue of the cerebral cortex and/or on putative pyrimidine binding sites in the brain controlling SRIF synthesis and/or release. It is possible that uridine in this way may improve recovery of neuronal function within SRIF-immunoreactive neurons of the cerebral cortex after severe hypoglycaemia (which also may be true in other states of reduced metabolic support). These findings suggest a possibility to use uridine in the treatment of Alzheimer's disease and Status epilepticus.
通过放射免疫分析程序，在胰岛素诱导的低血糖导致等电位脑电图模式的雄性大鼠的背侧海马结构和额顶叶皮质中，对胆囊收缩素（CCK）和生长抑素（SRIF）样免疫反应性进行了研究。已证明持续40分钟的严重低血糖会导致两个皮质区域中SRIF消失，但CCK样免疫反应性不会消失。研究发现，静脉注射尿苷而非生理盐水可显著抵消严重低血糖在两个皮质区域诱导的SRIF样免疫反应性的消失。尿苷本身不会改变血糖水平。有人提出，尿苷可能在严重低血糖时阻止皮质SRIF肽的释放和/或增加其合成，这可能是由于其对大脑皮质组织内的代谢（例如通过增强磷脂酰肌醇的再合成）和/或对控制SRIF合成和/或释放的大脑中假定的嘧啶结合位点的作用。尿苷可能以这种方式改善严重低血糖后大脑皮质中SRIF免疫反应性神经元的神经功能恢复（在其他代谢支持减少的状态下也可能如此）。这些发现提示了使用尿苷治疗阿尔茨海默病和癫痫持续状态的可能性。
