Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Department of Orthopaedic Surgery, Sapporo Maruyama Orthopaedic Hospital, Sapporo, Japan.
J Back Musculoskelet Rehabil. 2022;35(5):1035-1041. doi: 10.3233/BMR-210124.
Pain sensitization may be one of the mechanisms contributing to chronic low back pain (CLBP).
To evaluate the association between visceral fat, CLBP, and central sensitization (CS); describe the relationship between low back pain (LBP) intensity and CS; and identify possible correlation between visceral fat and LBP intensity.
Patients with CLBP were divided using their CS inventory (CSI) scores into low- (CSI < 40) and high-CSI (CSI ⩾ 40) subgroups. We compared computed tomography (CT) measurements and scores for association with pain according to the visual analogue scale (VAS) between the two groups.
The low-CSI and the high-CSI groups had 47 patients (67.1%; 21 men, 26 women) and 23 patients (32.9%; 11 men and 12 women), respectively. The high-CSI group had a significantly higher mean VAS score (p< 0.01) and estimated mean visceral fat area (p< 0.05) than the low-CSI group. There was a moderate positive correlation between VAS score and visceral fat (standardised partial regression coefficient: 0.659, p< 0.01) in the high-CSI group according to multiple linear regression analysis adjusted for age and sex.
Visceral fat is associated with CLBP, regardless of sex or age, and may be a potential therapeutic target for CLBP with CS.
疼痛敏化可能是导致慢性下背痛（CLBP）的机制之一。
评估内脏脂肪、CLBP 和中枢敏化（CS）之间的关联；描述下背痛（LBP）强度与 CS 之间的关系；并确定内脏脂肪与 LBP 强度之间的可能相关性。
根据 CS 量表（CSI）评分，将 CLBP 患者分为低 CSI（CSI<40）和高 CSI（CSI ⩾40）亚组。我们比较了两组之间 CT 测量值和根据视觉模拟量表（VAS）评分与疼痛的关联。
低 CSI 组和高 CSI 组分别有 47 名患者（67.1%；21 名男性，26 名女性）和 23 名患者（32.9%；11 名男性和 12 名女性）。高 CSI 组的平均 VAS 评分（p<0.01）和估计的平均内脏脂肪面积（p<0.05）明显高于低 CSI 组。多元线性回归分析调整年龄和性别后，高 CSI 组 VAS 评分与内脏脂肪之间存在中度正相关（标准化偏回归系数：0.659，p<0.01）。
无论性别或年龄如何，内脏脂肪与 CLBP 相关，它可能是 CS 型 CLBP 的潜在治疗靶点。
