Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Lu, Shanghai, 200032, China.
Chem Commun (Camb). 2022 Mar 15;58(22):3653-3656. doi: 10.1039/d1cc07136j.
A ring-opening/cyclization cascade reaction of α-brominated amide-tethered alkylidenecyclopropanes in the presence of photocatalyst 4CzIPN under visible-light irradiation was developed to afford polycyclic benzazepine derivatives in good yields with broad substrate scope and good functional tolerance. A plausible mechanism involving a halogen atom transfer (XAT) process and a radical chain process is proposed for this reaction. This study provides a concise and practical strategy for the synthesis of benzazepine derivatives.
在可见光照耀下，光催化剂 4CzIPN 的存在下，开发了一种 α-溴代酰胺键合亚烷基环丙烷的开环/环化级联反应，以良好的收率得到多环苯并氮杂卓衍生物，具有广泛的底物范围和良好的功能耐受性。提出了一种涉及卤原子转移（XAT）过程和自由基链过程的合理反应机制。该研究为苯并氮杂卓衍生物的合成提供了一种简洁实用的策略。
