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是什么决定了疫苗的价值?

What Drives the Value of a Vaccine?

作者信息

Hausdorff William P, Scheele Suzanne, Giersing Birgitte K

机构信息

Center for Vaccine Innovation and Access, PATH, 455 Massachusetts Ave NW, Washington, DC 20001, USA.

Faculty of Medicine, Université Libre de Bruxelles, 1050 Brussels, Belgium.

出版信息

Vaccines (Basel). 2022 Feb 12;10(2):282. doi: 10.3390/vaccines10020282.

DOI:10.3390/vaccines10020282
PMID:35214740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8874986/
Abstract

The development and licensure of a safe and highly efficacious vaccine has been a priority in international public health circles for decades and would represent a great scientific achievement. Nonetheless, in the context of increasingly crowded and costly childhood immunization programs, and with a myriad of other new and improved vaccines currently or soon on the market, there is no guarantee that even a highly effective vaccine would become a priority for adoption and introduction by the low- and middle-income countries that could benefit from it the most. We discuss here some of the major determinants and questions regarding the introduction of vaccines and the importance of developing a succinct, compelling public health value proposition.

摘要

几十年来,研发和批准一种安全且高效的疫苗一直是国际公共卫生界的首要任务,这将是一项重大的科学成就。然而,在儿童免疫规划日益拥挤且成本高昂的背景下,以及目前或即将上市的大量其他新型和改良疫苗的情况下,即使是一种高效疫苗,也不能保证会成为最能从中受益的低收入和中等收入国家采用和引入的优先选择。我们在此讨论一些关于疫苗引入的主要决定因素和问题,以及制定一个简洁、有说服力的公共卫生价值主张的重要性。

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本文引用的文献

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The Full Value of Vaccine Assessments (FVVA): a framework for assessing and communicating the value of vaccines for investment and introduction decision-making.疫苗评估的全部价值(FVVA):评估和沟通疫苗投资和引入决策价值的框架。
BMC Med. 2023 Jul 4;21(1):229. doi: 10.1186/s12916-023-02929-0.
2
Could a vaccine impact long-term health outcomes?: Summary report of an expert meeting to inform a vaccine public health value proposition, March 24 and 29, 2021.疫苗会影响长期健康结果吗?:2021年3月24日和29日关于为疫苗公共卫生价值主张提供信息的专家会议总结报告
Vaccine X. 2022 Sep 21;12:100218. doi: 10.1016/j.jvacx.2022.100218. eCollection 2022 Dec.
3
From Concept to Clinical Product: A Brief History of the Novel Invaplex Vaccine's Refinement and Evolution.从概念到临床产品:新型Invaplex疫苗的优化与演进简史。
Vaccines (Basel). 2022 Apr 1;10(4):548. doi: 10.3390/vaccines10040548.
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Potential impact and cost-effectiveness of injectable next-generation rotavirus vaccines in 137 LMICs: a modelling study.137 个中低收入国家中可注射的新一代轮状病毒疫苗的潜在影响和成本效益:一项建模研究。
Hum Vaccin Immunother. 2022 Dec 31;18(1):2040329. doi: 10.1080/21645515.2022.2040329. Epub 2022 Mar 3.
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Vaccines (Basel). 2022 Jan 20;10(2):149. doi: 10.3390/vaccines10020149.
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National stakeholder preferences for next-generation rotavirus vaccines: Results from a six-country study.国家利益相关者对下一代轮状病毒疫苗的偏好:来自六个国家的研究结果。
Vaccine. 2022 Jan 21;40(2):370-379. doi: 10.1016/j.vaccine.2021.11.009. Epub 2021 Dec 2.
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World Health Organization Expert Working Group: Recommendations for assessing morbidity associated with enteric pathogens.世界卫生组织专家工作组:评估肠道病原体相关发病率的建议。
Vaccine. 2021 Dec 20;39(52):7521-7525. doi: 10.1016/j.vaccine.2021.11.033. Epub 2021 Nov 24.
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EClinicalMedicine. 2021 Aug 13;39:101076. doi: 10.1016/j.eclinm.2021.101076. eCollection 2021 Sep.
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Value Health. 2021 Aug;24(8):1150-1157. doi: 10.1016/j.jval.2021.04.1273. Epub 2021 Jun 18.
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