Alkahtani Masfer, Zharkov Dmitrii K, Leontyev Andrey V, Shmelev Artemi G, Nikiforov Victor G, Hemmer Philip R
King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.
Institute for Quantum Science and Engineering, Texas A&M University, College Station, TX 77843, USA.
Nanomaterials (Basel). 2022 Feb 10;12(4):601. doi: 10.3390/nano12040601.
Unlike standard nanodiamonds (NDs), boron-doped nanodiamonds (BNDs) have shown great potential in heating a local environment, such as tumor cells, when excited with NIR lasers (808 nm). This advantage makes BNDs of special interest for hyperthermia and thermoablation therapy. In this study, we demonstrate that the negatively charged color center (NV) in lightly boron-doped nanodiamonds (BNDs) can optically sense small temperature changes when heated with an 800 nm laser even though the correct charge state of the NV is not expected to be as stable in a boron-doped diamond. The reported BNDs can sense temperature changes over the biological temperature range with a sensitivity reaching 250 mK/√Hz. These results suggest that BNDs are promising dual-function bio-probes in hyperthermia or thermoablation therapy as well as other quantum sensing applications, including magnetic sensing.
与标准纳米金刚石（NDs）不同，硼掺杂纳米金刚石（BNDs）在用近红外激光（808nm）激发时，在加热局部环境（如肿瘤细胞）方面显示出巨大潜力。这一优势使得BNDs在热疗和热消融治疗中备受关注。在本研究中，我们证明了轻度硼掺杂纳米金刚石（BNDs）中的带负电荷色心（NV）在用800nm激光加热时能够光学感知微小的温度变化，尽管预计NV在硼掺杂金刚石中的正确电荷态不如在未掺杂金刚石中稳定。报道的BNDs能够在生物温度范围内感知温度变化，灵敏度达到250 mK/√Hz。这些结果表明，BNDs在热疗或热消融治疗以及其他量子传感应用（包括磁传感）中是有前途的双功能生物探针。
