Kim Yung-Yoon, Sagara Kanta, Uezu Kazuya
Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Kitakyushu 808-0135, Japan.
Faculty of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Kitakyushu 808-0135, Japan.
Polymers (Basel). 2022 Feb 9;14(4):663. doi: 10.3390/polym14040663.
The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to adsorb the influenza virus, a functional group was introduced into a microfiber nonwoven fabric (MNWF) manufactured through radiation-induced graft polymerization (RIGP), and sialic acid was immobilized to mimic the sugar chain cluster effect. The functional group was used by coupling disodium iminodiacetate monohydrate (IDA) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and -acetylneuraminic acid (NANA) was selected for sialic acid. IDA-EDC was introduced into GMA MNWF with an average molar conversion of 47%. For NANA MNWF with a degree of grafting () of 87% introduced with sialic acid, 118.2 of 200 µg of aerosolized lectin was adsorbed, confirming that the maximum adsorption amount was 59.1%. In NANA MNWF of 100% or more , a tendency to decrease the amount of lectin adsorption was observed compared to NANA MNWF of 80-100% .
从过去到现在，流感病毒一直是危害人类健康的典型传染性病毒。我们推动了一种新型吸附剂的开发，该吸附剂能够以气溶胶形式吸附空气中的流感病毒。在本研究中，为开发一种吸附流感病毒的材料，通过辐射诱导接枝聚合（RIGP）制备的微纤维无纺布（MNWF）中引入了官能团，并固定化唾液酸以模拟糖链簇效应。通过将亚氨基二乙酸钠一水合物（IDA）和1-（3-二甲基氨基丙基）-3-乙基碳二亚胺盐酸盐（EDC）偶联来使用该官能团，唾液酸选择了N-乙酰神经氨酸（NANA）。IDA-EDC以平均摩尔转化率47%引入到GMA MNWF中。对于引入唾液酸且接枝度（）为87%的NANA MNWF，吸附了200μg雾化凝集素中的118.2μg，证实最大吸附量为59.1%。在接枝度为100%及以上的NANA MNWF中，与接枝度为80-100%的NANA MNWF相比，观察到凝集素吸附量有下降趋势。
