Quitkin F, Rifkin A, Klein D F
Am J Psychiatry. 1978 Jul;135(7):806-11. doi: 10.1176/ajp.135.7.806.
The authors examined how delusions and other psychotic features influenced treatment outcome with imipramine in patients with primary depression. Global improvement scores indicated that delusions or other evidence of psychosis do not contraindicate imipramine treatment. This finding does not support a recent report suggesting that deluded depressive patients should not be treated with imipramine. Possible explanations of the discrepancy between these two studies are discussed.
作者们研究了妄想及其他精神病性特征如何影响原发性抑郁症患者使用丙咪嗪的治疗效果。整体改善评分表明,妄想或其他精神病证据并不构成丙咪嗪治疗的禁忌。这一发现不支持最近一份报告所提出的观点,即患有妄想的抑郁症患者不应使用丙咪嗪进行治疗。本文讨论了这两项研究之间差异的可能解释。