Morita A, Kamoshita K, Ito T, Naito Y, Akiyama K, Kobayashi S
Arzneimittelforschung. 1986 Apr;36(4):680-3.
The occlusion of the femoral artery of rats induced reproducible hind limb lesions resembling thromboangiitis and obliterative arteriosclerosis. 17(R)-Methyl-20-isopropylidenecarbacyclin (CS-570), as well as alprostadil (PGE1), ticlopidine and pentoxifylline, inhibited the lesions. The occlusion of the femoral artery of rabbits caused elevation of the viscosity of the returning venous blood and echinocytic shape changes of erythrocytes. CS-570, as well as PGE1, also inhibited these changes. The decreased deformability of erythrocytes of rats under acidic conditions was improved by CS-570 and PGE1. The usefulness of CS-570 for the treatment of periferal arterial diseases was suggested.
大鼠股动脉闭塞可引发可重现的后肢损伤，类似于血栓闭塞性脉管炎和闭塞性动脉硬化。17(R)-甲基-20-异亚丙基卡前列环素（CS-570）以及前列地尔（PGE1）、噻氯匹定和己酮可可碱可抑制这些损伤。兔股动脉闭塞导致回流静脉血粘度升高以及红细胞出现棘状形态改变。CS-570以及PGE1也可抑制这些变化。CS-570和PGE1可改善酸性条件下大鼠红细胞变形性降低的情况。提示CS-570对周围动脉疾病的治疗有用。
