男性的睾酮、糖尿病风险和糖尿病预防。
Testosterone, Diabetes Risk, and Diabetes Prevention in Men.
机构信息
Medical School, University of Western Australia, Perth, Western Australia 6009, Australia; Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia 6150, Australia.
Freemasons Centre for Men's Health and Wellbeing, Medical School, University of Adelaide, Adelaide, South Australia 5000, Australia; Department of Endocrinology, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia; South Australian Health and Medical Research Institute, North Terrace, Adelaide, South Australia 5000, Australia.
出版信息
Endocrinol Metab Clin North Am. 2022 Mar;51(1):157-172. doi: 10.1016/j.ecl.2021.11.004. Epub 2022 Feb 8.
Middle-aged and older men with lower testosterone concentrations are more likely to have or to develop metabolic syndrome and type 2 diabetes. Central adiposity is a risk factor for metabolic syndrome and diabetes and predisposes to lower testosterone concentrations. Conversely, testosterone treatment reduces fat mass and insulin resistance. In a randomized controlled trial of 1007 men with either impaired glucose tolerance or newly diagnosed type 2 diabetes, 2 years of testosterone treatment on a background of lifestyle intervention reduced the risk of type 2 diabetes by 40%; this demonstrates the potential utility for testosterone pharmacotherapy to prevent diabetes in men.
中老年男性睾酮浓度较低，更有可能患有或发展为代谢综合征和 2 型糖尿病。中心性肥胖是代谢综合征和糖尿病的危险因素，并导致睾酮浓度降低。相反，睾酮治疗可减少脂肪量和胰岛素抵抗。在一项纳入 1007 名糖耐量受损或新诊断为 2 型糖尿病男性的随机对照试验中，在生活方式干预的基础上进行 2 年的睾酮治疗，使 2 型糖尿病的风险降低了 40%；这表明睾酮药物治疗在预防男性糖尿病方面具有潜在的应用价值。
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