Chandrasingh Sindhulina, Nair Sreeja
Department of Microbiology, Bangalore Baptist Hospital, Bellary Road, Hebbal, Bangalore 560005, Karnataka, India.
Department of Microbiology, Bangalore Baptist Hospital, Bellary Road, Hebbal, Bangalore 560005, Karnataka, India.
Indian J Med Microbiol. 2022 Apr-Jun;40(2):303-305. doi: 10.1016/j.ijmmb.2022.01.007. Epub 2022 Feb 22.
We aimed to study the rate of isoniazid (INH) resistance in Extrapulmonary Tuberculosis samples from a private care setting. A Line probe assay was performed on 74 culture isolates of Mycobacterium tuberculosis or directly on extrapulmonary samples received in our laboratory from 2018 to 2021. The INH mono-resistance among these extrapulmonary samples was 6.7%. (5 among 74) (95% CI: 1.04%-12.48%) Resistance to rifampicin was not detected. Increasing the availability and leveraging public private partnerships in hospitals for universal testing for INH resistance may increase detection of INH monoresistance in EP-TB and improve the strategy for TB elimination.
我们旨在研究私立医疗机构肺外结核样本中异烟肼（INH）耐药率。对74株结核分枝杆菌培养分离株进行了线性探针分析，或直接对2018年至2021年在我们实验室收到的肺外样本进行分析。这些肺外样本中的INH单耐药率为6.7%（74例中有5例）（95%置信区间：1.04%-12.48%），未检测到对利福平的耐药情况。提高医院中INH耐药性通用检测的可及性并利用公私伙伴关系，可能会增加肺外结核中INH单耐药性的检测，并改善结核病消除策略。
