Division of Neurosurgery, Department of Surgery, University Health Network/Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Division of Neurosurgery, Department of Surgery, University Health Network/Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.
World Neurosurg. 2022 May;161:e625-e634. doi: 10.1016/j.wneu.2022.02.072. Epub 2022 Feb 23.
Sellar arachnoid cysts (SACs) are rare lesions that require treatment only if symptomatic. The endoscopic endonasal approach has been widely used. Despite their simple cystic appearance and the straight-forward surgical intervention, important associated risks exist, with cerebrospinal fluid (CSF) leak the prevalent risk.
A retrospective analysis of patients with pathologically confirmed SAC between January 2006 and December 2019 was conducted. A homogeneous simple cyst-opening technique and skull base reconstruction with nasoseptal flaps was used.
A total of 10 patients were identified (7 women and 3 men; median age, 54.5 years; range, 20-77 years). Of the 10 patients, 8 had had newly diagnosed SACs and 2 patients had had recurrence from a previously microsurgically fenestrated SAC. Eight patients had presented with visual symptoms, one with visual symptoms and fatigue, and one with intractable headaches. Neuro-ophthalmological and endocrinological assessments had revealed visual field deficits in 6, visual acuity decline in 5, and hypopituitarism in 2 patients. The median calculated volume was 1.71 mL (range, 0.27-2.54 mL). Postoperatively, no CSF leak and no further surgical complications were noted. The visual field had improved in 4 of 6 patients and visual acuity had improved in 4 of 5 patients. Anterior pituitary function had improved in 1, worsened in 1, and remained stable in 8 patients. One patient had developed diabetes insipidus. One recurrence was recorded at 54 months postoperatively.
The results from the present study have shown that SACs can be effectively treated using a simple cyst-opening technique. The routine use of nasoseptal flaps significantly reduced the risk of CSF leakage without compromising nasal quality of life in the long term or mandating additional incisions. Long-term follow-up is important to monitor for late recurrence.
鞍上蛛网膜囊肿(SAC)是一种罕见的病变,只有在出现症状时才需要治疗。经鼻内镜手术已被广泛应用。尽管 SAC 表现为单纯的囊性病变,且手术干预相对简单,但仍存在重要的相关风险,其中以脑脊液(CSF)漏为主要风险。
对 2006 年 1 月至 2019 年 12 月期间经病理证实的 SAC 患者进行回顾性分析。采用单纯囊肿开窗技术和鼻中隔黏膜瓣颅底重建。
共纳入 10 例患者(7 例女性,3 例男性;中位年龄 54.5 岁;范围 20-77 岁)。其中 8 例为新发 SAC,2 例为既往显微镜下开窗的 SAC 复发。8 例患者表现为视力症状,1 例表现为视力症状伴乏力,1 例表现为难治性头痛。神经眼科和内分泌评估显示,6 例患者存在视野缺损,5 例患者视力下降,2 例患者存在垂体功能减退。计算的中位囊肿体积为 1.71ml(范围 0.27-2.54ml)。术后无 CSF 漏和其他手术并发症。6 例患者中,4 例患者的视野改善,5 例患者中,4 例患者的视力改善。1 例患者的垂体前叶功能改善,1 例患者的垂体前叶功能恶化,8 例患者的垂体前叶功能稳定。1 例患者发生尿崩症。术后 54 个月记录到 1 例复发。
本研究结果表明,采用单纯囊肿开窗技术可有效治疗 SAC。常规使用鼻中隔黏膜瓣可显著降低 CSF 漏的风险,而不会长期影响鼻腔生活质量或需要额外切口,也不会影响嗅觉。长期随访对于监测迟发性复发很重要。