Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
Biochem Pharmacol. 2022 Apr;198:114977. doi: 10.1016/j.bcp.2022.114977. Epub 2022 Feb 23.
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a multifunctional protein. MALT1 functions as an adaptor protein to assemble and recruit proteins such as B-cell lymphoma 10 (BCL10) and caspase-recruitment domain (CARD)-containing coiled-coil protein 11 (CARD11). Conversely it also acts as a paracaspase to cleave specified substrates. Because of its involvement in immunity, inflammation and cancer through its dual functions of scaffolding and catalytic activity, MALT1 is becoming a promising therapeutic target in B cell- and T cell-related diseases. There is growing evidence that the function of MALT1 is subtly modulated via post-translational modifications. This review summarized recent progress in relevant studies regarding the physiological and pathophysiological functions of MALT1, post-translational modifications of MALT1 and its role in B cell- and T cell- related diseases. In addition, the current available MALT1 inhibitors were also discussed.
黏膜相关淋巴组织淋巴瘤易位蛋白 1（MALT1）是一种多功能蛋白。MALT1 作为衔接蛋白，组装并募集 B 细胞淋巴瘤 10（BCL10）和含有衔接蛋白结构域（CARD）的卷曲螺旋蛋白 11（CARD11）等蛋白。相反，它也可以作为一种半胱天冬酶发挥作用，切割特定的底物。由于其通过支架和催化活性的双重功能参与免疫、炎症和癌症，MALT1 正在成为 B 细胞和 T 细胞相关疾病有前途的治疗靶点。越来越多的证据表明，MALT1 的功能通过翻译后修饰得到微妙调节。本综述总结了 MALT1 的生理和病理生理功能、MALT1 的翻译后修饰及其在 B 细胞和 T 细胞相关疾病中的作用的相关研究的最新进展。此外，还讨论了目前可用的 MALT1 抑制剂。
