Bosch-Bayard Jorge, Biscay Rolando J, Fernandez Thalia, Otero Gloria A, Ricardo-Garcell Josefina, Aubert-Vazquez Eduardo, Evans Alan C, Harmony Thalia
McGill Center for Integrative Neuroscience (MCIN), Ludmer Center for Neuroinformatics and Mental Health, Montreal Neurological Institute (MNI), McGill University, Montreal H3A2B4, Canada.
Centro de Investigación en Matemáticas, Guanajuato 36023, Mexico.
Neuroimage. 2022 May 15;252:119035. doi: 10.1016/j.neuroimage.2022.119035. Epub 2022 Feb 24.
The maturation of electroencephalogram (EEG) effective connectivity in healthy infants during the first year of life is described.
Participants: A cross-sectional sample of 125 healthy at-term infants, from 0 to 12 months of age, underwent EEG in a state of quiet sleep.
The EEG primary currents at the source were described with the sLoreta method. An unmixing algorithm was applied to reduce the leakage, and the isolated effective coherence, a direct and directed measurement of information flow, was calculated.
Initially, the highest indices of connectivity are at the subcortical nuclei, continuing to the parietal lobe, predominantly the right hemisphere, then expanding to temporal, occipital, and finally the frontal areas, which is consistent with the myelination process. Age-related connectivity changes were mostly long-range and bilateral. Connections increased with age, mainly in the right hemisphere, while they mainly decreased in the left hemisphere. Increased connectivity from 20 to 30 Hz, mostly at the right hemisphere. These findings were consistent with right hemisphere predominance during the first three years of life. Theta and alpha connections showed the greatest changes with age. Strong connectivity was found between the parietal, temporal, and occipital regions to the frontal lobes, responsible for executive functions and consistent with behavioral development during the first year. The thalamus exchanges information bidirectionally with all cortical regions and frequency bands.
The maturation of EEG connectivity during the first year in healthy infants is very consistent with synaptogenesis, reductions in synaptogenesis, myelination, and functional and behavioral development.
描述了健康婴儿在出生后第一年脑电图（EEG）有效连接性的成熟过程。
参与者：选取125名0至12个月大的足月健康婴儿作为横断面样本，在安静睡眠状态下接受脑电图检查。
采用sLoreta方法描述源处的EEG初级电流。应用解混算法减少泄漏，并计算孤立的有效相干性，这是一种对信息流的直接和定向测量。
最初，连接性最高的指标出现在皮质下核，随后延伸至顶叶，主要是右半球，然后扩展到颞叶、枕叶，最后是额叶，这与髓鞘形成过程一致。与年龄相关的连接性变化大多是长程和双侧的。连接性随年龄增加，主要在右半球，而在左半球主要减少。20至30赫兹的连接性增加，主要在右半球。这些发现与生命最初三年中右半球优势一致。θ波和α波连接随年龄变化最大。在顶叶、颞叶和枕叶区域与额叶之间发现了强连接，额叶负责执行功能，这与第一年的行为发展一致。丘脑与所有皮质区域和频段双向交换信息。
健康婴儿在第一年中EEG连接性的成熟与突触发生、突触发生减少、髓鞘形成以及功能和行为发展非常一致。
