Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana, 125004, India.
Department of Chemistry, Chaudhary Charan Singh Haryana Agricultural University, Hisar, Haryana, 125004, India.
Eur J Med Chem. 2022 Mar 15;232:114199. doi: 10.1016/j.ejmech.2022.114199. Epub 2022 Feb 15.
2-Pyridone core structure has attracted much attention due to its abundance in natural products of biological importance. 2-Pyridone derivatives display diverse biological activities. From being antimicrobial, antimalarial, antitumor, cardiotonic and anti-fibrotic agents to the induction of neurite outgrowth, they affect many biological processes. They find significant role in medicines, agriculture, pharmacophore designing and are also used as synthones for other heterocyclic compounds. Therefore, the main purpose of this review is to assess the biological pursuits of 2-pyridone compounds. In addition, this review presents the overview of synthesis of medicinally active 2-pyridones along with their biological activity done in the past two decades.
由于 2-吡啶酮核心结构在具有重要生物学意义的天然产物中大量存在，因此引起了广泛关注。2-吡啶酮衍生物具有多种生物活性。它们具有抗菌、抗疟、抗肿瘤、强心和抗纤维化作用，可诱导神经突生长，影响许多生物过程。它们在医药、农业、药效团设计中发挥着重要作用，也可用作其他杂环化合物的合成子。因此，本篇综述的主要目的是评估 2-吡啶酮化合物的生物研究进展。此外，本文还综述了过去二十年中具有药用活性的 2-吡啶酮的合成及其生物活性。
