Oda Fumiko, Uzawa Akiyuki, Ozawa Yukiko, Yasuda Manato, Kuwabara Satoshi
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
J Neuroimmunol. 2022 Apr 15;365:577833. doi: 10.1016/j.jneuroim.2022.577833. Epub 2022 Feb 19.
Immune-mediated necrotizing myopathy (IMNM) is a pathologically defined diagnosis of idiopathic inflammatory myopathies. Adequate studies on cytokines of IMNM is lacking. We measured serum levels of 27 cytokines/chemokines in 22 IMNM patients, 10 sporadic inclusion body myositis (IBM) patients, and 23 other neurological disorders (ONDs) patients. In IMNM patients, the correlations between clinical features and cytokine/chemokine levels, and changes in cytokine/chemokine levels after immunosuppressive therapy were examined. Compared with ONDs patients, IMNM patients had significantly increased serum levels of several cytokines. In particular, IP-10 and MIP-1α levels were prominently increased, decreased after immunosuppressive-therapy, and correlated with serum creatine kinase levels. IP-10 and MIP-1α could play important roles in the IMNM pathogenesis.
免疫介导性坏死性肌病（IMNM）是一种病理上定义的特发性炎性肌病诊断。目前缺乏对IMNM细胞因子的充分研究。我们测量了22例IMNM患者、10例散发性包涵体肌炎（IBM）患者和23例其他神经系统疾病（OND）患者血清中27种细胞因子/趋化因子的水平。在IMNM患者中，研究了临床特征与细胞因子/趋化因子水平之间的相关性，以及免疫抑制治疗后细胞因子/趋化因子水平的变化。与OND患者相比，IMNM患者血清中几种细胞因子水平显著升高。特别是，IP-10和MIP-1α水平显著升高，免疫抑制治疗后降低，且与血清肌酸激酶水平相关。IP-10和MIP-1α可能在IMNM发病机制中发挥重要作用。
