Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, PR China.
Research Center of Pharmaceutical Engineering Technology, Harbin University of Commerce, Harbin, Heilongjiang Province 150076, PR China.
Colloids Surf B Biointerfaces. 2022 May;213:112426. doi: 10.1016/j.colsurfb.2022.112426. Epub 2022 Feb 23.
ACGs (annonaceous acetogenins) possess excellent antitumor activity, but their serious accompanying toxicity has prevented their application in the clinic. To address this problem, we therefore constructed an intratumoral drug delivery system integrating chemotherapy and photothermal therapy. The PEGylation of polydopamine nanoparticles (PDA-PEG NPs) possessed an excellent biocompatibility with size of 70.96 ± 2.55 nm, thus can be used as good photothermal materials in the body. Moreover, PDA-PEG NPs can kill half of cancer cells under NIR (near-infrared) laser irradiation, and the survival rate of 4T1 cells is only 1% when ACG NPs and PDA-PEG NPs are combined. In vivo distribution studies showed that the 0.1 mg/kg ACGs NPs + PDA-PEG NPs + NIR group had the highest tumor inhibition rate, which was significantly superior to that of the 0.1 mg/kg ACGs NPs intratumoral injection group (82.65% vs. 59.08%). Altogether, the combination of PDA-PEG NPs + NIR with chemotherapy drugs may provide a feasible and effective strategy for the treatment of superficial tumors.
ACGs（番荔枝内酯）具有优异的抗肿瘤活性，但严重的伴随毒性阻止了它们在临床上的应用。为了解决这个问题，我们构建了一个将化疗和光热疗法集成在一起的肿瘤内药物输送系统。聚多巴胺纳米粒子（PDA-PEG NPs）的聚乙二醇化具有极好的生物相容性，粒径为 70.96±2.55nm，因此可以作为体内良好的光热材料。此外，PDA-PEG NPs 在近红外（NIR）激光照射下能杀死一半的癌细胞，而当 ACG NPs 和 PDA-PEG NPs 结合时，4T1 细胞的存活率仅为 1%。体内分布研究表明，0.1mg/kg ACGs NPs+PDA-PEG NPs+NIR 组的肿瘤抑制率最高，明显优于 0.1mg/kg ACGs NPs 瘤内注射组（82.65%比 59.08%）。总的来说，PDA-PEG NPs+NIR 联合化疗药物可能为治疗浅表肿瘤提供一种可行有效的策略。
