无法手术的头颈部骨和软组织肉瘤的碳离子放疗：前瞻性观察研究。
Carbon-ion Radiotherapy for Inoperable Head and Neck Bone and Soft-tissue Sarcoma: Prospective Observational Study.
机构信息
Gunma University Heavy Ion Medical Center, Maebashi, Japan;
Department of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
出版信息
Anticancer Res. 2022 Mar;42(3):1439-1446. doi: 10.21873/anticanres.15614.
BACKGROUND/AIM: Bone and soft-tissue sarcomas of the head and neck have very poor prognoses. This prospective study aimed to investigate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for bone and soft-tissue sarcoma of the head and neck.
PATIENTS AND METHODS
The present study was a prospective clinical study that included 10 consecutive patients diagnosed with bone and soft-tissue sarcoma of the head and neck who were treated with C-ion RT between 2012 and 2018 at our institution. C-Ion RT consisted of 70.4 Gy (relative biological effectiveness) in 16 fractions.
RESULTS
The 3-year local control, overall survival, and progression-free survival rates for patients overall were 72.9%, 77.8%, and 36%, respectively.
CONCLUSION
The present study demonstrated the efficacy of C-ion RT for bone and soft-tissue sarcoma of the head and neck; adverse events were within the expected range.
背景/目的：头颈部的骨和软组织肉瘤预后极差。本前瞻性研究旨在探讨碳离子放疗（C-ion RT）对头颈部骨和软组织肉瘤的疗效和安全性。
患者和方法
本研究为前瞻性临床研究，纳入 2012 年至 2018 年间在我院接受 C-ion RT 治疗的 10 例连续诊断为头颈部骨和软组织肉瘤的患者。C-ion RT 采用 70.4 Gy（相对生物学效应），分 16 次进行。
结果
患者的 3 年局部控制率、总生存率和无进展生存率分别为 72.9%、77.8%和 36%。
结论
本研究表明 C-ion RT 对头颈部骨和软组织肉瘤有效，不良反应在预期范围内。
Zotero 插件