普通涎腺多形性腺癌与乳头型和筛状型的比较结果。
Outcome of Ordinary Polymorphous Adenocarcinomas of the Salivary Glands in Comparison With Papillary and Cribriform Subtypes.
机构信息
Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
Institute for Hematopathology, Hamburg, Germany;
出版信息
Anticancer Res. 2022 Mar;42(3):1455-1463. doi: 10.21873/anticanres.15616.
BACKGROUND/AIM: Polymorphous adenocarcinoma (PAC) is a low-grade salivary gland malignancy in contrast to variants with papillary (PAP) or cribriform (CASG) architecture and confers the second most common malignancy of minor salivary glands. Our study aimed to identify prognostic factors and to evaluate histomorphological and molecular diagnostic criteria of PACs.
PATIENTS AND METHODS
A series of 155 PACs, including 10 PAPs and 12 CASGs from the population-based Cancer Registry of North Rhine-Westphalia (LKR-NRW) and the Hamburg Salivary Gland Reference Centre (HRC) were analyzed.
RESULTS
One fifth of the tumors were located in the major salivary glands and PACS/CASGS invariably lacked p40 expression. Fifty-two percent of PACs showed a PRKD1 E710D mutation. Ordinary PACs had a disease-specific 10-year survival probability of 97% compared to 90% when combining PAPs and CASGs. T-stage at diagnosis was a prognostic factor with 98% for stages T1/T2 versus 75% for T3/T4.
CONCLUSION
Diagnostic algorithms for the PAC/CASG spectrum of tumors need to be improved and should include molecular markers.
背景/目的：多形性腺癌（PAC）是一种低级别的唾液腺癌，与具有乳头状（PAP）或筛状（CASG）结构的变体形成对比，是小唾液腺的第二大常见恶性肿瘤。我们的研究旨在确定预后因素，并评估 PAC 的组织形态学和分子诊断标准。
患者和方法
对基于人群的北莱茵-威斯特法伦癌症登记处（LKR-NRW）和汉堡唾液腺参考中心（HRC）的 155 例 PAC 患者（包括 10 例 PAP 和 12 例 CASG）进行了分析。
结果
五分之一的肿瘤位于大唾液腺中，PACS/CASGS 始终缺乏 p40 表达。52%的 PAC 显示 PRKD1 E710D 突变。普通 PAC 的疾病特异性 10 年生存率为 97%，而将 PAP 和 CASG 合并后则为 90%。诊断时的 T 期是一个预后因素，T1/T2 期的生存率为 98%，而 T3/T4 期的生存率为 75%。
结论
PAC/CASG 肿瘤谱的诊断算法需要改进，应包括分子标志物。
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