Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Genes Chromosomes Cancer. 2023 May;62(5):297-300. doi: 10.1002/gcc.23122. Epub 2023 Feb 3.
Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation.
涎腺筛状腺癌（CASG）是一种罕见的涎腺肿瘤。本报告描述了一例具有新型 PPP2R2A::PRKD1 融合的 CASG。一位 58 岁女性因左下第三磨牙区域附近的口腔内肿块就诊。组织学检查、免疫组织化学染色（p63+、p40-）和肿瘤位置的形态特征提示为 CASG。然而，由于肿瘤内可能存在局灶性双相成分，因此进行 RNA 测序以确认诊断。随后发现的新型 PPP2R2A::PRKD1 融合增加了不断发展的唾液腺肿瘤分子图谱。此外，我们报告 CASG 可能显示出对先前存在的涎腺导管的一些包埋，这可能被误诊为具有肌上皮分化的肿瘤细胞。
