3D 打印二尖瓣结构的开发用于经导管器械建模中的组织和器械变形。

Development of 3D Printed Mitral Valve Constructs for Transcatheter Device Modeling of Tissue and Device Deformation.

机构信息

The Methodist DeBakey Heart & Vascular Center, 6550 Fannin Street, Suite 1851, Houston, TX, 77030, USA.

Department of Bioengineering, Rice University, 6566 Main St., Houston, TX, 77030, USA.

出版信息

Ann Biomed Eng. 2022 Apr;50(4):426-439. doi: 10.1007/s10439-022-02927-y. Epub 2022 Feb 26.

Abstract

Transcatheter mitral valve repair (TMVR) therapies offer a minimally invasive alternative to surgical mitral valve (MV) repair for patients with prohibitive surgical risks. Pre-procedural planning and associated medical device modeling is primarily performed in silico, which does not account for the physical interactions between the implanted TMVR device and surrounding tissue and may result in poor outcomes. We developed 3D printed tissue mimics for modeling TMVR therapies. Structural properties of the mitral annuli, leaflets, and chordae were replicated from multi-material blends. Uniaxial tensile testing was performed on the resulting composites and their mechanical properties were compared to those of their target native components. Mimics of the MV annulus printed in homogeneous strips approximated the tangent moduli of the native mitral annulus at 2% and 6% strain. Mimics of the valve leaflets printed in layers of different stiffnesses approximated the force-strain and stress-strain behavior of native MV leaflets. Finally, mimics of the chordae printed as reinforced cylinders approximated the force-strain and stress-strain behavior of native chordae. We demonstrated that multi-material 3D printing is a viable approach to the development of tissue phantoms, and that printed patient-specific geometries can approximate the local deformation force which may act upon devices used for TMVR therapies.

摘要

经导管二尖瓣修复术(TMVR)为手术风险极高的患者提供了一种微创二尖瓣(MV)修复替代方法。术前规划和相关医疗器械建模主要在计算机上进行,无法考虑植入 TMVR 装置与周围组织之间的物理相互作用,可能导致结果不佳。我们开发了用于模拟 TMVR 疗法的 3D 打印组织模拟物。二尖瓣瓣环、瓣叶和腱索的结构特性通过多材料混合物进行复制。对得到的复合材料进行单轴拉伸测试,并将其机械性能与目标天然组件的机械性能进行比较。在均匀条带中打印的 MV 瓣环模拟物在 2%和 6%应变时接近天然二尖瓣瓣环的切线模量。用不同硬度层打印的瓣叶模拟物近似模拟天然 MV 瓣叶的力-应变和应力-应变行为。最后,作为增强圆柱体打印的腱索模拟物近似模拟天然腱索的力-应变和应力-应变行为。我们证明了多材料 3D 打印是开发组织模型的一种可行方法,并且打印的患者特定几何形状可以近似作用于 TMVR 治疗中使用的装置的局部变形力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af78/8917041/6b588142242d/10439_2022_2927_Fig1_HTML.jpg

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