Sun B W, Huang J M
Department of Burns and Plastic Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Feb 20;38(2):109-113. doi: 10.3760/cma.j.cn501120-20211122-00391.
Neutrophils have always been considered as a short-lived and homogeneous cell type in the innate immune system, which have limited pro-inflammatory or anti-inflammatory effects. However, in recent 10 years, the understanding of neutrophils has been undergoing some kind of revival as researches progressed. The researches on the heterogeneity of neutrophils and the mechanism of their interaction with other immune cells have promoted the researchers to re-understand the physiological and pathophysiological roles of neutrophils. In the following decades, with the development of single-cell sequencing technology, spatial transcriptome sequencing technology, and multi-omics combined sequencing technology, researchers will have a better understanding of the biological behaviors of neutrophils. This paper briefly reviews the biological behaviors of neutrophils and their roles in various diseases in recent years.
中性粒细胞一直被认为是固有免疫系统中寿命短暂且同质化的细胞类型，其促炎或抗炎作用有限。然而，在最近十年里，随着研究的进展，对中性粒细胞的认识正在经历某种复兴。对中性粒细胞异质性及其与其他免疫细胞相互作用机制的研究促使研究人员重新认识中性粒细胞的生理和病理生理作用。在接下来的几十年里，随着单细胞测序技术、空间转录组测序技术和多组学联合测序技术的发展，研究人员将对中性粒细胞的生物学行为有更深入的了解。本文简要综述了中性粒细胞的生物学行为及其近年来在各种疾病中的作用。
