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急性A型主动脉壁内血肿的个体化治疗方式

Tailored treatment modality in acute type A intramural hematoma.

作者信息

Kim Myeong Su, Kim Tae-Hoon, Lee Ha, Song Suk-Won, Yoo Kyung-Jong

机构信息

Department of Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Department of Cardiovascular Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

出版信息

J Thorac Cardiovasc Surg. 2023 Nov;166(5):1400-1410. doi: 10.1016/j.jtcvs.2022.01.037. Epub 2022 Feb 3.

Abstract

OBJECTIVES

Intramural hematoma may be generated by a minimal intimal tear. Most surgeries for acute type A intramural hematoma are performed on the proximal aorta alone regardless of the intimal tear site. Under the assumption that major adverse aortic events (MAAEs) would be related to the location of primary intimal tear, we reviewed preoperative computed tomography scan findings.

METHODS

Sixty patients with acute type A intramural hematoma who underwent surgery from January 2008 to December 2019 were retrospectively analyzed. The maximal diameter, maximal thickness of the intramural hematoma, and hematoma thickness ratio of the ascending and descending aortae were measured. MAAEs were defined as newly developed aortic dissection, rupture, newly developed penetrating aortic ulcer (PAU), enlargement of the PAU, and aortic death.

RESULTS

The number of patients with PAU in the descending aorta (dPAU) was significantly higher in the MAAE (+) group. The MAAE (+) group showed lower measurements of the ascending aorta and higher measurements of the descending aorta than the MAAE (-) group. In the univariate analysis, dPAU, hematoma thickness ratio of the ascending and descending aortae, and descending aorta hematoma thickness >8.58 mm were risk factors of MAAE. Intimal tear noted intraoperatively and ascending aorta hematoma thickness >10.25 mm were protective factors of MAAE.

CONCLUSIONS

Aortopathies (ie, PAU, ulcer-like projections, and the hematoma thickness ratio) are important clues to determine the location of intimal tear. Occurrence of MAAEs seems to be highly related to the pathology of the descending aorta. The modalities of treatment for stable acute type A intramural hematoma that do not meet the existing guidelines should be tailored to the location of the intimal tear.

摘要

目的

壁内血肿可能由微小内膜撕裂产生。大多数急性A型壁内血肿手术仅在主动脉近端进行,而不考虑内膜撕裂部位。基于主要不良主动脉事件(MAAEs)可能与原发性内膜撕裂部位相关的假设,我们回顾了术前计算机断层扫描结果。

方法

对2008年1月至2019年12月期间接受手术的60例急性A型壁内血肿患者进行回顾性分析。测量壁内血肿的最大直径、最大厚度以及升主动脉和降主动脉的血肿厚度比。MAAEs定义为新发主动脉夹层、破裂、新发穿透性主动脉溃疡(PAU)、PAU扩大和主动脉死亡。

结果

MAAE(+)组降主动脉PAU(dPAU)患者数量显著更高。与MAAE(-)组相比,MAAE(+)组升主动脉测量值较低,而降主动脉测量值较高。在单因素分析中,dPAU、升主动脉和降主动脉的血肿厚度比以及降主动脉血肿厚度>8.58 mm是MAAE的危险因素。术中发现的内膜撕裂和升主动脉血肿厚度>10.25 mm是MAAE的保护因素。

结论

主动脉病变(即PAU、溃疡样突出和血肿厚度比)是确定内膜撕裂部位的重要线索。MAAEs的发生似乎与降主动脉的病理高度相关。对于不符合现有指南的稳定型急性A型壁内血肿,治疗方式应根据内膜撕裂部位进行调整。

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