University of Illinois at Chicago College of Medicine, Chicago, Illinois. Electronic address: https://twitter.com/ravityagi200.
Clinical Research, Argon Medical Devices, Inc., Frisco, Texas.
J Vasc Interv Radiol. 2022 Mar;33(3):249-254.e1. doi: 10.1016/j.jvir.2021.10.037.
An ovine iliac vein thrombosis model was devised to test a wall-contacting rotational thrombectomy device. Thrombosis was successfully induced in 9 sheep with an average clot length of 31 mm ± 12 and >60% vessel occlusion on angiography. The thrombus was subsequently removed, maintaining normal intraoperative pulmonary arterial pressure (5.9 mm Hg ± 3.6) and complete distal reperfusion after thrombectomy. Additionally, the sheep were without signs of vascular trauma or embolic complications on gross necropsy and histopathologic analysis. The findings from this study support the use of an ovine iliac deep vein thrombosis model for testing of a lower extremity thrombectomy device.
设计了一种绵羊髂静脉血栓模型来测试一种与血管壁接触的旋转血栓切除术装置。在 9 只绵羊中成功诱导了血栓形成，平均血栓长度为 31mm ± 12，血管造影显示 >60%的血管闭塞。随后将血栓切除，保持术中肺动脉压正常（5.9mmHg ± 3.6），血栓切除后完全再灌注。此外，在大体解剖和组织病理学分析中，绵羊没有血管创伤或栓塞并发症的迹象。这项研究的结果支持使用绵羊髂深静脉血栓模型来测试下肢血栓切除术装置。
