Department of population and Family health, Faculty of Public Health, Jumma University, Jimma, Ethiopia.
Departments of Internal Medicine, Jimma Medical Center, Jimma University, Jimma, Ethiopia.
Ethiop J Health Sci. 2021 Sep;31(5):925-936. doi: 10.4314/ejhs.v31i5.3.
Ethiopia has been motivated to achieve a goal of "appointment spacing model approach care." However, little has been documented on the predictor of mortality and challenges of sustainable HIV care. Therefore, the aim of this study was to determine predictors of mortality among adult people living with HIV/AIDS on antiretroviral therapy (ART).
A retrospective cohort study was conducted on 676 adult people living with HIV who enrolled to ART clinic from September 01, 2012 - August 30, 2016. Multivariable Cox Regression analysis was done where adjusted hazard ratio (AHR)with corresponding 95% confidence interval (CI) at P value ≤ 0.05 cut of point was used to identify predictors of mortality.
The total person-time contributed was 28,209 person-months with an overall mortality incidence rate of 11 per 1000 person-months observation. The cumulative mortality incidence among females over the study period was 16.8% (64/382). Severe undernourishment and moderate malnutrition at baseline, younger age, female sex, single, divorced, illiterate, lack of disclosure, advanced WHO clinical stage, seeking treatment outside catchment area, rural residence and immunological failure were found to be independent predictors of mortality.
Poor nutritional status at baseline, advanced stage of HIV disease, occurrence of treatment failure, female sex, substance abuse, lack of social support, immunological failure, clinical failure, and younger age, low level of education and poor physical access to healthcare facility were found to be important predictors of mortality. Intervening, those factors as routine and part of the appointment spacing model care can improve survival of PLWHA.
埃塞俄比亚一直致力于实现“预约间隔模式护理”的目标。然而,关于死亡率和可持续艾滋病毒护理的挑战,相关记录很少。因此,本研究旨在确定接受抗逆转录病毒疗法(ART)的艾滋病毒/艾滋病成人患者的死亡率预测因素。
对 2012 年 9 月 1 日至 2016 年 8 月 30 日期间在抗逆转录病毒治疗诊所登记的 676 名艾滋病毒感染者进行了回顾性队列研究。采用多变量 Cox 回归分析,使用调整后的危险比(AHR)和相应的 95%置信区间(CI),以 P 值≤0.05 为截断点,确定死亡率的预测因素。
总观察时间为 28209 人月,总死亡率为 11/1000 人月。研究期间,女性累积死亡率为 16.8%(64/382)。基线时严重营养不足和中度营养不良、年龄较小、女性、单身、离婚、文盲、未披露、世卫组织临床分期较晚、在非收治区域寻求治疗、农村居住和免疫失败是死亡率的独立预测因素。
基线时营养状况差、艾滋病毒疾病晚期、治疗失败、女性、滥用药物、缺乏社会支持、免疫失败、临床失败以及年龄较小、教育程度低、获得医疗保健的身体条件差是死亡的重要预测因素。这些因素可以作为常规措施并纳入预约间隔模式护理,以提高艾滋病毒感染者/艾滋病患者的生存率。