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Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders.综合 RNA-seq 和全基因组数据分析表明，神经精神疾病中神经元细胞类型亚群富集。
Mol Psychiatry. 2022 Feb;27(2):947-955. doi: 10.1038/s41380-021-01324-6. Epub 2021 Nov 1.
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Shared genetic architecture across psychiatric disorders.精神障碍的共享遗传结构。
Psychol Med. 2021 Oct;51(13):2210-2216. doi: 10.1017/S0033291721000829. Epub 2021 Mar 17.
3
Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci.全基因组关联分析帕金森病和精神分裂症揭示了共享的遗传结构，并确定了新的风险基因座。
Biol Psychiatry. 2021 Feb 1;89(3):227-235. doi: 10.1016/j.biopsych.2020.01.026. Epub 2020 Feb 8.
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Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease.亨廷顿病中精神和认知症状的遗传风险。
Biol Psychiatry. 2020 May 1;87(9):857-865. doi: 10.1016/j.biopsych.2019.12.010. Epub 2019 Dec 17.
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.精神障碍的八大类疾病中的基因组关系、新位点和多效机制。
Cell. 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020.
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Lumpers and splitters: the bumpy road to precision medicine.概括者与细分者：精准医学的崎岖之路。
Eur Heart J. 2019 Oct 21;40(40):3292-3296. doi: 10.1093/eurheartj/ehz644.
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The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges.精神疾病共享多基因结构的新出现模式、概念和方法学挑战。
Psychiatr Genet. 2019 Oct;29(5):152-159. doi: 10.1097/YPG.0000000000000234.
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A cross-disorder connectome landscape of brain dysconnectivity.跨疾病连接组学研究揭示大脑连接异常的全景图谱
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Science. 2018 Jun 22;360(6395). doi: 10.1126/science.aap8757.
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Nat Rev Genet. 2018 Sep;19(9):581-590. doi: 10.1038/s41576-018-0018-x.

Editorial: Cross-disorder Genetics in Neuropsychiatry.

作者信息

Van Assche Evelien, Schulte Eva C, Andreassen Ole A, Smeland Olav B, Luykx Jurjen J

机构信息

Department of Psychiatry, University of Münster, Münster, Germany.

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.

出版信息

Front Neurosci. 2022 Feb 9;16:826300. doi: 10.3389/fnins.2022.826300. eCollection 2022.

DOI:10.3389/fnins.2022.826300
PMID:35221906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8863965/
Abstract
摘要