Zhao Yao-Zhong, Dai Yong-Zhao, Nie Ke
School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China.
Front Pharmacol. 2022 Feb 9;12:790784. doi: 10.3389/fphar.2021.790784. eCollection 2021.
Chemotherapy-induced nausea and vomiting (CINV), a common side effect in antineoplastic treatment, dramatically decreases the quality of life as well as the compliance of cancer patients. Although numerous antiemetic agents have been used for CINV treatment, its adverse reactions as well as its inadequate control toward delayed emesis still limit its clinical usage. Traditional Chinese medicine (TCM), with more than 3,000 years of practical history in Asia, has been successfully applied to mitigate chemotherapy-induced side effects. Growing attention is drawn to the antiemetic effect of TCM against CINV due to its promising therapeutic property and higher safety recently. In this review, we summarize the classic antiemetic TCM-based treatment and its mechanisms, so as to provide a theoretical basis for further investigations of TCM against CINV in the future.
化疗引起的恶心和呕吐（CINV）是抗肿瘤治疗中常见的副作用，会显著降低癌症患者的生活质量和依从性。尽管众多止吐药已用于CINV治疗，但其不良反应以及对延迟性呕吐控制不足仍限制了其临床应用。在亚洲有着3000多年实践历史的传统中医（TCM）已成功应用于减轻化疗引起的副作用。由于其近期有前景的治疗特性和更高的安全性，中医对CINV的止吐作用日益受到关注。在本综述中，我们总结了基于中医的经典止吐治疗及其机制，以便为未来进一步研究中医抗CINV提供理论依据。
