连翘果实水提物通过抑制 NLRP3 炎性小体激活减轻顺铂诱导的大鼠高岭土摄食（异食癖）。
Forsythiae Fructus aqueous extract attenuates cisplatin-induced kaolin consumption (pica) by inhibiting NLRP3 inflammasome activation in rats.
机构信息
School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, China.
School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
出版信息
Biosci Biotechnol Biochem. 2021 Aug 25;85(9):2054-2064. doi: 10.1093/bbb/zbab126.
The present study was conducted to evaluate the effect of Forsythiae Fructus aqueous extract (FAE) against cisplatin-induced emesis and to explore the antiemetic mechanism of FAE by focusing on NLRP3 inflammasome activation in a rat pica model. Our results showed that FAE significantly ameliorated cisplatin-induced acute and delayed pica in rats. Moreover, FAE improved the gastrointestinal histopathological injury and reduced the levels of serum ROS, IL-1β, and IL-18 in cisplatin-treated rats. In addition, the expressions of NLRP3, ASC, caspase-1, and IL-1β and the colocalization of the NLRP3 with ASC or caspase-1 in rat gastric antrum and ileum were also suppressed by FAE. Taken together, our findings indicate that FAE has a therapeutic effect against CINV, which may be related to its inhibition of the activation of NLRP3 inflammasome.
本研究旨在评估连翘果水提物（FAE）对顺铂诱导的呕吐的作用，并通过关注 NLRP3 炎性体激活在大鼠异食癖模型中探索 FAE 的止吐机制。我们的结果表明，FAE 可显著改善顺铂诱导的大鼠急性和迟发性异食癖。此外，FAE 改善了顺铂处理大鼠的胃肠道组织病理学损伤，并降低了血清 ROS、IL-1β 和 IL-18 的水平。此外，FAE 还抑制了 NLRP3、ASC、半胱天冬酶-1 和 IL-1β 在大鼠胃窦和回肠中的表达，以及 NLRP3 与 ASC 或半胱天冬酶-1 的共定位。综上所述，我们的研究结果表明，FAE 对 CINV 具有治疗作用，这可能与其抑制 NLRP3 炎性体的激活有关。
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