• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

（前）肾素受体通过释放成纤维细胞生长因子-23调节大鼠的磷稳态。

(Pro)renin Receptor Regulates Phosphate Homeostasis in Rats Releasing Fibroblast Growth Factor-23.

作者信息

Lu Aihua, Pu Min, Mo Shiqi, Su Jiahui, Hu Jiajia, Li Chunling, Wang Weidong, Yang Tianxin

机构信息

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, UT, United States.

出版信息

Front Physiol. 2022 Feb 11;13:784521. doi: 10.3389/fphys.2022.784521. eCollection 2022.

DOI:10.3389/fphys.2022.784521
PMID:35222071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8874195/
Abstract

Phosphate (Pi) is one of the basic necessities required for sustenance of life and its metabolism largely relies on excretory function of the kidney, a process chiefly under the endocrine control of bone-derived fibroblast growth factor 23 (FGF23). However, knowledge gap exists in understanding the regulatory loop responsible for eliciting phophaturic response to Pi treatment. Here, we reported a novel role of (pro)renin receptor (PRR) in mediating phosphaturic response to Pi treatment upregulation of FGF23 production. Male Sprague-Dawley rats were pretreated for 5 days osmotic pump-driven infusion of a PRR antagonist PRO20 or vehicle, and then treated with high Pi (HP) solution as drinking fluid for the last 24 h. PRO20 reduced HP-induced Pi excretion by 42%, accompanied by blunted upregulation of circulating FGF23 and parathyroid hormone (PTH) and downregulation of renal Na/Pi-IIa expression. In cultured osteoblast cells, exposure to HP induced a 1.56-fold increase in FGF23 expression, which was blunted by PRO20 or siRNA against PRR. Together, these results suggest that activation of PRR promotes phosphaturic response through stimulation of FGF23 production and subsequent downregulation of renal Na/Pi-IIa expression.

摘要

磷酸盐（Pi）是维持生命所需的基本物质之一，其代谢很大程度上依赖于肾脏的排泄功能，这一过程主要受骨源性成纤维细胞生长因子23（FGF23）的内分泌控制。然而，在理解引发对Pi治疗的磷尿反应的调节环路方面存在知识空白。在此，我们报道了（前）肾素受体（PRR）在介导对Pi治疗的磷尿反应（即FGF23产生的上调）中的新作用。雄性Sprague-Dawley大鼠经渗透泵驱动输注PRR拮抗剂PRO20或载体预处理5天，然后在最后24小时用高Pi（HP）溶液作为饮用水进行处理。PRO20使HP诱导的Pi排泄减少了42%，同时循环FGF23和甲状旁腺激素（PTH）的上调减弱，以及肾Na/Pi-IIa表达下调。在培养的成骨细胞中，暴露于HP会使FGF23表达增加1.56倍，而PRO20或针对PRR的小干扰RNA（siRNA）会使其减弱。总之，这些结果表明PRR的激活通过刺激FGF23的产生以及随后下调肾Na/Pi-IIa表达来促进磷尿反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/98fd58a0ca29/fphys-13-784521-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/d66821764229/fphys-13-784521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/38f7c76c7948/fphys-13-784521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/4e5ec51467b3/fphys-13-784521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/180b235a4cf4/fphys-13-784521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/64c4b6950f21/fphys-13-784521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/92a00c8424b3/fphys-13-784521-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/f24fc873cb60/fphys-13-784521-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/c0b093227eeb/fphys-13-784521-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/98fd58a0ca29/fphys-13-784521-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/d66821764229/fphys-13-784521-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/38f7c76c7948/fphys-13-784521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/4e5ec51467b3/fphys-13-784521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/180b235a4cf4/fphys-13-784521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/64c4b6950f21/fphys-13-784521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/92a00c8424b3/fphys-13-784521-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/f24fc873cb60/fphys-13-784521-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/c0b093227eeb/fphys-13-784521-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8874195/98fd58a0ca29/fphys-13-784521-g009.jpg

相似文献

1
(Pro)renin Receptor Regulates Phosphate Homeostasis in Rats Releasing Fibroblast Growth Factor-23.（前）肾素受体通过释放成纤维细胞生长因子-23调节大鼠的磷稳态。
Front Physiol. 2022 Feb 11;13:784521. doi: 10.3389/fphys.2022.784521. eCollection 2022.
2
(Pro)Renin receptor regulates potassium homeostasis through a local mechanism.（前体）肾素受体通过局部机制调节钾稳态。
Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F641-F656. doi: 10.1152/ajprenal.00043.2016. Epub 2016 Jul 20.
3
Effect of hydrolysis-resistant FGF23-R179Q on dietary phosphate regulation of the renal type-II Na/Pi transporter.抗水解性FGF23-R179Q对肾脏II型钠/磷转运体饮食磷调节的影响
Pflugers Arch. 2003 Aug;446(5):585-92. doi: 10.1007/s00424-003-1084-1. Epub 2003 Jul 8.
4
Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model.成纤维细胞生长因子 23 在慢性肾脏病大鼠模型的肾脏中被上调。
PLoS One. 2018 Mar 8;13(3):e0191706. doi: 10.1371/journal.pone.0191706. eCollection 2018.
5
Vitamin D and type II sodium-dependent phosphate cotransporters.维生素D与II型钠依赖性磷酸盐共转运体
Contrib Nephrol. 2013;180:86-97. doi: 10.1159/000346786. Epub 2013 May 6.
6
Bone mineralization is regulated by signaling cross talk between molecular factors of local and systemic origin: the role of fibroblast growth factor 23.骨矿化是由局部和全身来源的分子因子的信号串扰调节的：成纤维细胞生长因子 23 的作用。
Biofactors. 2014 Nov-Dec;40(6):555-68. doi: 10.1002/biof.1186. Epub 2014 Oct 29.
7
Fgf23 and parathyroid hormone signaling interact in kidney and bone.成纤维细胞生长因子23（Fgf23）与甲状旁腺激素信号在肾脏和骨骼中相互作用。
Mol Cell Endocrinol. 2016 Nov 15;436:224-39. doi: 10.1016/j.mce.2016.07.035. Epub 2016 Aug 4.
8
Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system.肾髓质（前）肾素受体通过激活局部肾素-血管紧张素系统，在大鼠血管紧张素II诱导的高血压中发挥作用。
BMC Med. 2015 Nov 10;13:278. doi: 10.1186/s12916-015-0514-1.
9
Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization.成纤维细胞生长因子23在调节全身磷酸盐稳态和细胞外基质矿化的骨-肾轴中的新作用。
Curr Opin Nephrol Hypertens. 2007 Jul;16(4):329-35. doi: 10.1097/MNH.0b013e3281ca6ffd.
10
[Discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis].α-klotho和FGF23的发现为钙磷稳态带来了新见解
Clin Calcium. 2008 Jul;18(7):923-34.

引用本文的文献

1
Understanding renal phosphate handling: unfinished business.理解肾脏磷酸盐处理：未竟之业。
Curr Opin Nephrol Hypertens. 2023 Jul 1;32(4):394-400. doi: 10.1097/MNH.0000000000000889. Epub 2023 Apr 12.
2
Inhibitory effect of (pro)renin receptor decoy inhibitor PRO20 on endoplasmic reticulum stress during cardiac remodeling.（前）肾素受体诱饵抑制剂PRO20对心脏重塑过程中内质网应激的抑制作用。
Front Pharmacol. 2022 Aug 12;13:940365. doi: 10.3389/fphar.2022.940365. eCollection 2022.

本文引用的文献

1
Isolation and Characterization of Three Sodium-Phosphate Cotransporter Genes and Their Transcriptional Regulation in the Grass Carp .草鱼三种钠-磷协同转运蛋白基因的分离与鉴定及其转录调控
Int J Mol Sci. 2020 Nov 3;21(21):8228. doi: 10.3390/ijms21218228.
2
COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.COX-2 非依赖性激活肾（前）肾素受体参与大鼠 DOCA-盐高血压的发生。
Am J Physiol Renal Physiol. 2020 Oct 1;319(4):F647-F653. doi: 10.1152/ajprenal.00112.2020. Epub 2020 Aug 17.
3
Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism.
体力活动对甲状旁腺激素和钙磷代谢的调节作用。
Int J Mol Sci. 2020 Jul 29;21(15):5388. doi: 10.3390/ijms21155388.
4
(Pro)renin receptor contributes to hypoxia/reoxygenation-induced apoptosis and autophagy in myocardial cells via the beta-catenin signaling pathway.（前）肾素受体通过β-连环蛋白信号通路促进心肌细胞缺氧/复氧诱导的细胞凋亡和自噬。
Physiol Res. 2020 Jul 16;69(3):427-438. doi: 10.33549/physiolres.934210. Epub 2020 May 29.
5
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice.促炎型 P2Y14 受体抑制可预防小鼠缺血性急性肾损伤。
J Clin Invest. 2020 Jul 1;130(7):3734-3749. doi: 10.1172/JCI134791.
6
ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury.埃拉贝拉通过拮抗肾内肾素-血管紧张素系统来降低血压并防止肾脏损伤。
Am J Physiol Renal Physiol. 2020 May 1;318(5):F1122-F1135. doi: 10.1152/ajprenal.00606.2019. Epub 2020 Mar 16.
7
(Pro)renin receptor contributes to pregnancy-induced sodium-water retention in rats via activation of intrarenal RAAS and α-ENaC.(Pro) 肾素受体通过激活肾内 RAAS 和 α-ENaC 促进大鼠妊娠诱导的钠水潴留。
Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F530-F538. doi: 10.1152/ajprenal.00411.2018. Epub 2018 Oct 31.
8
Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.（原）肾素受体在白蛋白过载诱导大鼠肾病中的作用。
Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1759-F1768. doi: 10.1152/ajprenal.00071.2018. Epub 2018 May 30.
9
Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion.收集管主细胞而非闰细胞的原肾素受体调节肾脏钠水排泄。
Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F607-F617. doi: 10.1152/ajprenal.00122.2018. Epub 2018 May 23.
10
Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis.钙-甲状旁腺激素-维生素 D 轴的生理学。
Front Horm Res. 2018;50:1-13. doi: 10.1159/000486060. Epub 2018 Mar 29.