Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Department of Endocrinology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Front Endocrinol (Lausanne). 2022 Feb 10;13:832102. doi: 10.3389/fendo.2022.832102. eCollection 2022.
To compare the effects of real-time and retrospective flash glucose monitoring (FGM) on daily glycemic control and lifestyle in patients with type 2 diabetes on premix insulin therapy.
A total of 172 patients using premix insulin, with HbA1c ≥ 7.0% (56 mmol/mol), or the time below the target (TBR) ≥ 4%, or the coefficient of variation (CV) ≥36% during the screening period, were randomly assigned to retrospective FGM (n = 89) or real-time FGM group (n = 83). Another two retrospective or real-time 14-day FGMs were performed respectively, 1 month apart. Both groups received educations and medication adjustment after each FGM. Time in range (3.9~10.0 mmol/l, TIR) increased significantly after 3 months in the real-time FGM group (6.5%) compared with the retrospective FGM group (-1.1%) ( = 0.014). HbA1c decreased in both groups (both < 0.01). Real-time FGMs increased daily exercise time compared with the retrospective group ( = 0.002).
Real-time FGM with visible blood glucose improves daily glycemic control and diabetes self-care behaviors better than retrospective FGM in patients with type 2 diabetes on premix insulin therapy.
比较实时和回顾性动态血糖监测（FGM）对接受预混胰岛素治疗的 2 型糖尿病患者日常血糖控制和生活方式的影响。
共有 172 名使用预混胰岛素的患者，其糖化血红蛋白（HbA1c）≥7.0%（56mmol/mol），或目标时间范围内（TBR）＜4%，或变异系数（CV）≥36%，在筛选期接受回顾性 FGM（n=89）或实时 FGM 组（n=83）。两组患者分别进行了另外两次回顾性或实时 14 天 FGM 检查，相隔 1 个月。每组在每次 FGM 后都接受了教育和药物调整。与回顾性 FGM 组（-1.1%）相比，实时 FGM 组在 3 个月时 TIR（3.9~10.0mmol/l）显著增加（6.5%）（=0.014）。两组的 HbA1c 均下降（均<0.01）。与回顾性组相比，实时 FGM 组增加了每日运动时间（=0.002）。
与回顾性 FGM 相比，接受预混胰岛素治疗的 2 型糖尿病患者中，实时 FGM 可改善日常血糖控制和糖尿病自我护理行为。
