Department of Orthopaedics and Traumatology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.
Department of Orthopaedics and Traumatology, Dr. Nafiz Korez Sincan State Hospital, Ankara, Turkey.
Afr Health Sci. 2021 Sep;21(3):1250-1258. doi: 10.4314/ahs.v21i3.35.
To evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in giant cell tumor of bone (GCT).
The patients with GCT were identified in the hospital records and pre-treatment complete blood count results were acquired retrospectively. Whether preoperative NLR lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) values had prognostic significance in predicting recurrence was evaluated by Receiver operating curve (ROC) analysis. Furthermore, the prognostic value of NLR was evaluated by Multivariable Cox Regression analysis.
There were 96 patients with GCT. It was found that only NLR values had prognostic significance for predicting recurrence (AUC:0.647; 95% CI:0.533-0.762; P=0.021). The statistically significant cut-off value of NLR for predicting recurrence was ≥2.25. NLR was ≥2.25 in 51% (n = 49) of patients. Multivariable analysis showed that NLR ≥2.25 (HR=2.9, 95% CI:1.3-6.6; p=0.009) and lung metastasis (HR=7.9, 95% CI:2.2-28.2; p=0.001) were independent factors of recurrence. In patients with lung metastasis and patients with NLR ≥2.25, recurrence was observed in a sooner period (Log rank test; p=0.001; p=0.009, respectively).
Our findings showed that NLR is a new and promising inflammation-based prognostic factor in GCT patients.
评估中性粒细胞与淋巴细胞比值（NLR）在骨巨细胞瘤（GCT）中的预后意义。
从医院病历中确定 GCT 患者，并回顾性获取治疗前全血细胞计数结果。通过接收者操作曲线（ROC）分析评估术前 NLR、淋巴细胞与单核细胞比值（LMR）和血小板与淋巴细胞比值（PLR）值是否对预测复发具有预后意义。此外，通过多变量 Cox 回归分析评估 NLR 的预后价值。
共有 96 例 GCT 患者。结果发现，只有 NLR 值对预测复发具有预后意义（AUC：0.647；95%CI：0.533-0.762；P=0.021）。预测复发的 NLR 统计学显著截断值为≥2.25。51%（n=49）的患者 NLR≥2.25。多变量分析显示，NLR≥2.25（HR=2.9，95%CI：1.3-6.6；p=0.009）和肺转移（HR=7.9，95%CI：2.2-28.2；p=0.001）是复发的独立因素。在有肺转移和 NLR≥2.25的患者中，复发发生的时间更早（Log rank 检验；p=0.001；p=0.009）。
我们的研究结果表明，NLR 是 GCT 患者一种新的、有前途的炎症相关预后因素。
