Wladimiroff J W, Tonge H M, Stewart P A, Reuss A
Eur J Obstet Gynecol Reprod Biol. 1986 Jun;22(1-2):23-8. doi: 10.1016/0028-2243(86)90086-9.
Doppler blood flow velocity waveforms in the umbilical artery and fetal internal carotid artery were recorded in a total of 10 patients with severe intrauterine growth retardation (IUGR) and marked oligohydramnios to establish a fetal or utero-placental origin of IUGR. Gestational age varied between 28 and 37 wk. Negative maternal serology ruled out fetal infections. In six patients, IUGR was associated with abnormal flow velocity waveforms, indicating utero-placental insufficiency. Following delivery, these infants showed no structural defects; moderate to marked placental infarction was documented in 4 out of 6 cases. In the remaining four patients, IUGR was associated with normal flow velocity waveforms, suggesting a fetal origin of the IUGR. Following delivery, all four infants revealed structural defects, only one of which was diagnosed prenatally. Twice an abnormal karyotype was the underlying cause. There was no placental infarction. These preliminary data suggest that combined recording of the flow velocity waveform in the above-mentioned vessels may provide valuable additional information as to the cause of IUGR and as such be helpful in determining obstetric management.
对10例重度宫内生长受限（IUGR）并伴有明显羊水过少的患者记录脐动脉和胎儿颈内动脉的多普勒血流速度波形，以确定IUGR的胎儿或子宫-胎盘起源。孕周在28至37周之间。孕妇血清学检查阴性排除了胎儿感染。6例患者中，IUGR与异常血流速度波形相关，提示子宫-胎盘功能不全。分娩后，这些婴儿无结构缺陷；6例中有4例记录到中度至重度胎盘梗死。其余4例患者中，IUGR与正常血流速度波形相关，提示IUGR起源于胎儿。分娩后，所有4例婴儿均有结构缺陷，其中仅1例在产前被诊断出。两次染色体核型异常是根本原因。无胎盘梗死。这些初步数据表明，联合记录上述血管的血流速度波形可能为IUGR的病因提供有价值的额外信息，从而有助于确定产科处理方法。
