Greis Ari, Renslo Bryan, Wilson-Poe Adrianne R, Liu Conan, Radakrishnan Anjithaa, Ilyas Asif M
Department of Medical Cannabis, Rothman Orthopaedic Institute, Philadelphia, USA.
Department of Medical Cannabis, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA.
Cureus. 2022 Jan 20;14(1):e21452. doi: 10.7759/cureus.21452. eCollection 2022 Jan.
Background This study investigates whether the use of medical cannabis (MC) in patients with chronic back pain is associated with a decreased opioid prescription. Methods The study included 186 patients with chronic back pain who were certified for MC use. The average morphine milligram equivalent (MME)/day of opioid prescriptions filled within the six months prior to MC certification was compared to that of six months after. Pain and disability questionnaires were distributed at three, six, and nine months post-certification. Results Patients who started at less than 15 MME/day and patients who started at greater than 15 MME/day decreased from 15.1 to 11.0 (n = 186, p < 0.01), 3.5 to 2---.1 (n = 134, p < 0.01), and 44.9 to 33.9 (n = 52, p < 0.01), respectively. Pain and disability scores were improved at follow-up as well. Conclusion MC use reduces opioid prescription for patients with chronic back pain and improves pain and disability scores.
背景 本研究调查慢性背痛患者使用医用大麻（MC）是否与阿片类药物处方量减少有关。方法 该研究纳入了186名经认证可使用MC的慢性背痛患者。将MC认证前六个月内开具的阿片类药物处方的平均每日吗啡毫克当量（MME）与认证后六个月的进行比较。在认证后的三个月、六个月和九个月发放疼痛和残疾问卷。结果 起始剂量低于15 MME/天的患者以及起始剂量高于15 MME/天的患者，MME分别从15.1降至11.0（n = 186，p < 0.01）、从3.5降至2.1（n = 134，p < 0.01）以及从44.9降至33.9（n = 52，p < 0.01）。随访时疼痛和残疾评分也有所改善。结论 使用MC可减少慢性背痛患者的阿片类药物处方量，并改善疼痛和残疾评分。
