Pigakis Konstantinos M, Voulgaris Athanasios, Nena Evagelia, Kontopodi Aggeliki, Steiropoulos Paschalis
Respiratory Medicine, Creta Interclinic Hospital, Heraklion, GRC.
Respiratory Medicine, Faculty of Health Sciences, Democritus University of Thrace, Alexandroupoli, GRC.
Cureus. 2022 Jan 30;14(1):e21729. doi: 10.7759/cureus.21729. eCollection 2022 Jan.
Patients with obstructive sleep apnea (OSA) frequently complain of fatigue during exercise. Treatment with continuous positive airway pressure (CPAP) ameliorates OSA-related symptoms and may reduce the burden of OSA on coexistent diseases. However, the role of CPAP on exercise capacity in OSA has not been fully investigated.
The aim of this study is to assess exercise capacity in a group of newly diagnosed OSA patients, without known comorbidities, following treatment with CPAP.
Consecutively diagnosed OSA patients by polysomnography completed the International Physical Activity Questionnaire (IPAQ) and underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing at baseline of OSA diagnosis three months after adherence to CPAP treatment.
A total of 40 OSA patients (Apnea-Hypopnea Index (ΑΗΙ)>15 events/hour) of whom 29 (72.5%) males with an average age of 42±2.5 years were enrolled in the study. OSA patients had a mean peak oxygen uptake (V̇O) value of 40.3 ±8.4 ml/kg/min (77.7±15%), which was improved after three months on CPAP treatment, 47.6±7.9 ml/kg/min (92.9±10.5%). (p=0.002). In addition, patients' mean work (W) value increased significantly from baseline to three months of treatment with CPAP (101.5±30 watts vs 78.6±18.5 watts. p=0.015, respectively). There were no significant differences in terms of physical activity, as noted in IPAQ, before and after OSA therapy (p=0.075).
In the present study, OSA is associated with impaired exercise capacity, which seems to be improved after short-term treatment with PAP. Further evidence is warranted to elucidate whether CPET could be routinely used to monitor treatment responses of OSA with CPAP.
阻塞性睡眠呼吸暂停（OSA）患者经常抱怨运动时疲劳。持续气道正压通气（CPAP）治疗可改善与OSA相关的症状，并可能减轻OSA对并存疾病的负担。然而，CPAP对OSA患者运动能力的作用尚未得到充分研究。
本研究的目的是评估一组新诊断的、无已知合并症的OSA患者在接受CPAP治疗后的运动能力。
通过多导睡眠图连续诊断的OSA患者完成国际体力活动问卷（IPAQ），并在OSA诊断基线、坚持CPAP治疗三个月后进行心肺运动试验（CPET）和肺功能测试。
共有40例OSA患者（呼吸暂停低通气指数（ΑΗΙ）>15次/小时）纳入研究，其中29例（72.5%）为男性，平均年龄42±2.5岁。OSA患者的平均峰值摄氧量（V̇O）值为40.3±8.4 ml/kg/min（77.7±15%），在CPAP治疗三个月后有所改善，为47.6±7.9 ml/kg/min（92.9±10.5%）。（p=0.002）。此外，患者的平均做功（W）值从基线到CPAP治疗三个月时显著增加（分别为101.5±30瓦和78.6±18.5瓦。p=0.015）。如IPAQ所示，OSA治疗前后的体力活动没有显著差异（p=0.075）。
在本研究中，OSA与运动能力受损有关，短期PAP治疗后运动能力似乎有所改善。有必要进一步证据阐明CPET是否可常规用于监测OSA患者CPAP治疗反应。
