Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Tongshan Road 209, Xuzhou 221004, China.
Org Lett. 2022 Mar 11;24(9):1817-1821. doi: 10.1021/acs.orglett.2c00270. Epub 2022 Feb 28.
A range of medium-sized cyclic ethers (5 to 11 membered) have been effectively synthesized through intramolecular reductive coupling of dialdehydes initiated by 50 ppm to 0.5% of AgNTf with hydrosilane at 25 °C. The catalytic system is also suitable for the coupling of two different monoaldehydes to provide unsymmetrical ethers. This protocol features broad functional group compatibility, high product diversity, high efficiency, and utility in the late-stage modification of complex biorelevant molecules.
通过在 25°C 下用氢化硅烷引发 50ppm 至 0.5%的 AgNTf 对二醛进行分子内还原偶联，有效地合成了一系列中等大小的环醚（5 到 11 元环）。该催化体系也适用于两种不同的单醛的偶联，以提供不对称醚。该方案具有广泛的官能团兼容性、高产物多样性、高效率和在复杂生物相关分子的后期修饰中的实用性。
