Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.
Department of Chemistry, University of Georgia, 140 Cedar Street, Athens, Georgia 30602, United States.
Org Lett. 2022 Mar 11;24(9):1833-1836. doi: 10.1021/acs.orglett.2c00349. Epub 2022 Feb 28.
We describe a formal synthesis of 10-aza-9-oxakalkitoxin, the hydroxalog of the cytotoxic marine natural product kalkitoxin, that features Mukaiyama Markovnikov silyl peroxidation of a terminal alkene and N-O bond formation as the central enabling steps.
我们描述了 10-氮杂-9-氧杂卡利毒素的一种全合成方法,卡利毒素是一种具有细胞毒性的海洋天然产物,它的羟化产物,其特征步骤是 Mukaiyama Markovnikov 硅基过氧化末端烯烃和 N-O 键形成。