通过镍/光氧化还原双催化与亚硫酸盐进行脱氧 C-S 键偶联。
Deoxygenative C-S Bond Coupling with Sulfinates via Nickel/Photoredox Dual Catalysis.
机构信息
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Hunan Xiangtan 411105, China.
Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China.
出版信息
Org Lett. 2022 Mar 11;24(9):1865-1870. doi: 10.1021/acs.orglett.2c00478. Epub 2022 Feb 28.
The C-S bond formation from aryl halides and thiols has been well established under various catalytic systems. In this work, user-friendly sulfinates have been exploited as an efficient sulfenylating reagent in the C-S couplings through visible-light-induced photo/nickel dual catalysis under base- and external reductant-free conditions. A large number of aryl sulfide products were accessed with high selectivity and high tolerance of various functionalities.
芳基卤化物和硫醇之间的 C-S 键形成在各种催化体系中已经得到很好的建立。在这项工作中，通过可见光诱导的光/镍双催化，在无碱和无外加还原剂的条件下，使用了用户友好的亚磺酸盐作为有效的硫代试剂，用于 C-S 偶联反应。通过可见光诱导的光/镍双催化，在无碱和无外加还原剂的条件下，大量的芳基硫醚产物以高选择性和对各种官能团的高耐受性得到了合成。
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