442339All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
75143Gauhati Medical College and Hospital, Guwahati, Assam, India.
Trop Doct. 2022 Apr;52(2):304-306. doi: 10.1177/00494755221080587. Epub 2022 Feb 28.
Atypical agents such as Mycoplasma, Legionella, Chlamydia species, and Coxiella burnetii (Q-fever agent) are responsible for some adult community-acquired pneumonia (CAP). Insufficient studies on this topic can be blamed for the failure to include atypical pathogens in empirical management. We followed adult CAP cases for two years, and samples (respiratory and serum) were tested by culture, ELISA (IgM, IgG, and IgA), and PCR. A risk factor analysis was performed. Overall in 21.3% adult CAP patients, atypical agents found were Mycoplasma pneumoniae (51.5%), Legionella pneumophila (28.8%), and Chlamydophila pneumoniae (19.7%). However, amongst patients <60 years of age and in the summer season, the proportion of atypical agents increased significantly. There is thus a need to re-examine empirical antibiotic regimes.
一些非典型病原体，如支原体、军团菌、衣原体和贝纳柯克斯体（Q 热病原体），也可引起成人社区获得性肺炎（CAP）。由于对该主题的研究不足，未能将非典型病原体纳入经验性治疗中。我们对 2 年内的成人 CAP 病例进行了随访，并通过培养、ELISA（IgM、IgG 和 IgA）和 PCR 检测了呼吸道和血清样本。进行了风险因素分析。在所有成人 CAP 患者中，51.5%的患者中检测到肺炎支原体，28.8%的患者中检测到嗜肺军团菌，19.7%的患者中检测到肺炎衣原体。然而，在＜60 岁和夏季的患者中，非典型病原体的比例显著增加。因此，有必要重新审查经验性抗生素治疗方案。
