VA Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California, USA.
San Francisco Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
Alzheimers Dement. 2022 Dec;18(12):2627-2636. doi: 10.1002/alz.12617. Epub 2022 Feb 28.
Use of online registries to efficiently identify older adults with cognitive decline and Alzheimer's disease (AD) is an approach with growing evidence for feasibility and validity. Linked biomarker and registry data can facilitate AD clinical research.
We collected blood for plasma biomarker and genetic analysis from older adult Brain Health Registry (BHR) participants, evaluated feasibility, and estimated associations between demographic variables and study participation.
Of 7150 participants invited to the study, 864 (12%) enrolled and 629 (73%) completed remote blood draws. Participants reported high study acceptability. Those from underrepresented ethnocultural and educational groups were less likely to participate.
This study demonstrates the challenges of remote blood collection from a large representative sample of older adults. Remote blood collection from > 600 participants within a short timeframe demonstrates the feasibility of our approach, which can be expanded for efficient collection of plasma AD biomarker and genetic data.
利用在线注册系统有效地识别认知能力下降和阿尔茨海默病（AD）的老年人是一种越来越可行和有效的方法。关联的生物标志物和注册数据可以促进 AD 临床研究。
我们从老年大脑健康注册（BHR）参与者中采集了血液用于血浆生物标志物和基因分析，评估了可行性，并估计了人口统计学变量与研究参与之间的相关性。
在邀请参加研究的 7150 名参与者中，有 864 人（12%）入组，629 人（73%）完成了远程采血。参与者报告了很高的研究接受度。来自代表性不足的族裔文化和教育群体的参与者参与的可能性较低。
本研究表明，从大量代表性老年人群中远程采集血液存在挑战。在短时间内从 600 多名参与者中远程采集血液证明了我们方法的可行性，这可以扩展为有效采集 AD 生物标志物和遗传数据。
