Wiegand Susanne, Dietz Andreas, Wichmann Gunnar, Kunz Viktor
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Universitätsklinikum Leipzig, Leipzig.
Laryngorhinootologie. 2022 Mar;101(3):249-258. doi: 10.1055/a-1525-6600. Epub 2022 Feb 28.
Since treatment of elderly patients with head and neck cancer is often challenging due to preexisting comorbidities, continuous efforts are required to raise awareness for frailty, which is a multidimensional state of diminished physiologic reserve resulting in decreased resiliency and increased vulnerability to stressors. Frailty is a predictor of poor clinical outcomes in head and neck cancer patients, but until now there is no standardization of frailty assessment. Pretherapeutic frailty assessment among head and neck cancer patients should be incorporated into routine multidisciplinary management to predict adverse outcomes and tailor a personalized treatment. This article would like to explain the complex syndrome frailty and its importance for head and neck oncology.
由于老年头颈癌患者常因既有合并症而使治疗颇具挑战性，因此需要持续努力提高对衰弱的认识，衰弱是一种生理储备减少的多维度状态，会导致恢复力下降以及对应激源的易感性增加。衰弱是头颈癌患者临床预后不良的一个预测指标，但迄今为止，衰弱评估尚无标准化。头颈癌患者的治疗前衰弱评估应纳入常规多学科管理，以预测不良结局并制定个性化治疗方案。本文旨在阐释复杂的衰弱综合征及其在头颈肿瘤学中的重要性。
