Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Exercise Physiology, Mahabad Branch, Islamic Azad University, Mahabad, Iran.
Andrologia. 2022 Jun;54(5):e14394. doi: 10.1111/and.14394. Epub 2022 Feb 28.
The present study aimed to investigate the effects of resistance training, Phoenix dactylifera extract, and testosterone enanthate injection on luteinizing hormone receptor, claudin-1, cingulin, and zonula occludens in the prostate tissues of adult rats. 30 male rats were divided into six groups: (1) control, (2) resistance training, (3) Phoenix dactylifera extract, (4) testosterone enanthate, (5) resistance training+Phoenix dactylifera extract, and (6) resistance training + testosterone enanthate. After completing the treatments and resistance training, all rats were sacrificed via anaesthesia. The results showed that resistance training, Phoenix dactylifera, and testosterone enanthate significantly increased the luteinizing hormone receptor, claudin-1, cingulin, and zonula occludens gene expression levels in the prostate. The resistance training treatment, along with Phoenix dactylifera + testosterone enanthate, exerted synergic effects on the prostate luteinizing hormone receptor levels and claudin-1 gene expression. In conclusion, Phoenix dactylifera, as a natural compound with fewer side effects than testosterone injection, can be used to enhance athletic performance. Besides, considering the potential benefits of Phoenix dactylifera, it can be considered in the treatment of testosterone deficiency; however, further research is needed.
本研究旨在探讨阻力训练、刺果番荔枝提取物和庚酸睾酮注射对成年大鼠前列腺组织中黄体生成素受体、紧密连接蛋白-1、连接蛋白和闭合小带的影响。将 30 只雄性大鼠分为六组：（1）对照组；（2）阻力训练组；（3）刺果番荔枝提取物组；（4）庚酸睾酮组；（5）阻力训练+刺果番荔枝提取物组；（6）阻力训练+庚酸睾酮组。完成治疗和阻力训练后，所有大鼠均通过麻醉处死。结果表明，阻力训练、刺果番荔枝和庚酸睾酮显著增加了前列腺中黄体生成素受体、紧密连接蛋白-1、连接蛋白和闭合小带的基因表达水平。阻力训练与刺果番荔枝+庚酸睾酮联合治疗对前列腺黄体生成素受体水平和紧密连接蛋白-1 基因表达具有协同作用。综上所述，刺果番荔枝作为一种比睾酮注射副作用更少的天然化合物，可以用于提高运动表现。此外，鉴于刺果番荔枝的潜在益处，它可以考虑用于治疗睾酮缺乏症，但仍需要进一步研究。
