Singh Gurinder
Micro Labs GmbH, Frankfurt, Germany
Turk J Pharm Sci. 2022 Feb 28;19(1):104-109. doi: 10.4274/tjps.galenos.2020.89577.
Resveratrol is a natural compound (an antioxidant) and exhibits numerous therapeutic activities. From a pharmacokinetic perspective, it is unclear whether resveratrol targets the site of action after oral administration because of quick metabolism and excretion that creates doubt on the biological application of the high doses characteristically used for clinical trials. However, these limitations act as a barrier and a challenge for the development of new delivery systems. Recently, gene delivery offers various advantages and has provided treatment options for diseases that are beyond the reach of traditional approaches. The objective of gene therapy for genetic diseases is to achieve durable expression of the therapeutic gene at a level sufficient to alleviate or cure disease symptoms with minimal adverse events. The perception of the molecular and cellular mechanisms steering to therapy and vector-related hindrances have caused in the progress of extremely complex gene delivery with enhanced protection and effectiveness. With the help of gene therapy, it could be possible to target the delivery of resveratrol directly into the host cells and bypass its pharmacokinetic limitations and enhancement of its therapeutic effect. This review is to provide a holistic view of the development of resveratrol gene treatment as a powerful option to treat various deadly diseases.
白藜芦醇是一种天然化合物（抗氧化剂），具有多种治疗活性。从药代动力学角度来看，口服白藜芦醇后是否靶向作用部位尚不清楚，因为其快速代谢和排泄使得常用于临床试验的高剂量的生物学应用受到质疑。然而，这些局限性对新型给药系统的开发构成了障碍和挑战。近来，基因递送具有多种优势，为传统方法难以治疗的疾病提供了治疗选择。基因治疗遗传性疾病的目标是使治疗性基因持久表达，达到足以缓解或治愈疾病症状且不良事件最少的水平。对导向治疗的分子和细胞机制以及载体相关障碍的认识推动了极其复杂的基因递送的发展，使其具有更高的保护作用和有效性。借助基因治疗，有可能将白藜芦醇直接递送至宿主细胞，绕过其药代动力学限制并增强其治疗效果。本综述旨在全面介绍白藜芦醇基因治疗作为治疗各种致命疾病的有力选择的发展情况。
