Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China.
Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital, Shanghai, 20092, China; Department of Neurosurgery, Shanghai Jiaotong University School of Medicine, Xinhua Hospital Chongming Branch, Shanghai, 202150, China.
Auris Nasus Larynx. 2022 Oct;49(5):782-789. doi: 10.1016/j.anl.2022.02.005. Epub 2022 Feb 26.
To investigate whether serum gonadal hormone levels are correlated to the development of facial synkinesis following Bell's palsy in postmenopausal women and man.
A total of 149 patients with Bell's palsy were enrolled in this study. All patients were instructed in standard treatment strategy by expert staff from their first visit. The degree of synkinesis was evaluated at 12 months after the onset of facial nerve palsy based on the synkinesis scores of Sunnybrook facial grading system. The patients were divided into two groups by gender.
Serum estradiol levels were significantly higher in patients with facial synkinesis than in patients without facial synkinesis following Bell's palsy in postmenopausal female. Male patients with facial synkinesis following Bell's palsy had a higher serum estradiol and testosterone levels. Baseline ENoG values (OR=11.144, 95% CI=1.001-124.126, p=0.008) and serum estradiol levels (OR=1.145, 95% CI=1.033-1.270, p=0.010) were the two independent predictors for facial synkinesis in postmenopausal female patients. Meanwhile, baseline ENoG values (OR=5.312, 95% CI=0.626-45.069, p=0.035), HbA1c values (OR=27.470, 95% CI=2.001-43.084, p=0.016), serum E2 levels (OR=1.298, 95% CI=1.092-1.542, p=0.003), and serum testosterone levels (OR=1.892, 95% CI=1.309-2.734, p=0.001) were the independent predictors for facial synkinesis in male patients.
Serum estradiol levels are associated with the development of facial synkinesis following Bell's palsy in postmenopausal female patients. Serum estradiol and testosterone levels are associated with the development of facial synkinesis following Bell's palsy in male patients. Serum gonadal hormone levels might be acted as potential biomarker for predicting facial synkinesis following Bell's palsy.
探讨绝经后女性和男性贝尔氏面瘫后面神经麻痹后面部联带运动的发生是否与血清性腺激素水平有关。
本研究共纳入 149 例贝尔氏面瘫患者。所有患者均由专家工作人员首次就诊时给予标准治疗策略。根据 Sunnybrook 面部分级系统的联带运动评分，在面瘫后 12 个月评估联带运动程度。根据性别将患者分为两组。
绝经后女性贝尔氏面瘫后面神经麻痹后面部联带运动患者的血清雌二醇水平明显高于无面部联带运动患者。男性贝尔氏面瘫后面神经麻痹后面部联带运动患者的血清雌二醇和睾酮水平较高。基线 ENoG 值（OR=11.144，95%CI=1.001-124.126，p=0.008）和血清雌二醇水平（OR=1.145，95%CI=1.033-1.270，p=0.010）是绝经后女性患者面部联带运动的两个独立预测因子。同时，基线 ENoG 值（OR=5.312，95%CI=0.626-45.069，p=0.035）、HbA1c 值（OR=27.470，95%CI=2.001-43.084，p=0.016）、血清 E2 水平（OR=1.298，95%CI=1.092-1.542，p=0.003）和血清睾酮水平（OR=1.892，95%CI=1.309-2.734，p=0.001）是男性患者面部联带运动的独立预测因子。
血清雌二醇水平与绝经后女性贝尔氏面瘫后面神经麻痹后面部联带运动的发生有关。血清雌二醇和睾酮水平与男性贝尔氏面瘫后面神经麻痹后面部联带运动的发生有关。血清性腺激素水平可能是预测贝尔氏面瘫后面部联带运动的潜在生物标志物。
