Ross Emily C, Olivera Gabriela C, Barragan Antonio
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 09 Stockholm, Sweden.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 09 Stockholm, Sweden.
Trends Parasitol. 2022 Jun;38(6):450-461. doi: 10.1016/j.pt.2022.02.003. Epub 2022 Feb 25.
The blood-brain barrier (BBB) efficiently protects the central nervous system (CNS) from infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable capability to establish latent cerebral infection in humans and other vertebrates. In addition to the proposed mechanisms for access to the brain parenchyma, recent findings highlight a paramount role played by the BBB in restricting parasite passage and minimizing parasite loads in the brain. Consistent with clinically asymptomatic primary infections in humans, mounting evidence indicates that the original colonization of the brain by T. gondii encompasses previously unappreciated, nondisruptive translocation processes that precede the onset of parasite-limiting immune responses.
血脑屏障（BBB）能有效保护中枢神经系统（CNS）免受感染侵害。然而，顶复门寄生虫刚地弓形虫具有在人类和其他脊椎动物中建立潜伏性脑部感染的显著能力。除了已提出的进入脑实质的机制外，最近的研究结果凸显了血脑屏障在限制寄生虫通过和减少脑中寄生虫负荷方面所起的至关重要的作用。与人类临床上无症状的原发性感染一致，越来越多的证据表明，刚地弓形虫对脑部的最初定植涉及在寄生虫限制免疫反应开始之前未被充分认识的、无破坏性的转运过程。
