Guo Yuchen, Guo Zhongyu, Zhang Lilan, Yoshimura Chihiro, Ye Zimi, Yu Pengfei, Qian Yao, Hatano Yuta, Wang Jieqiong, Niu Junfeng
Research Center for Eco-environmental Engineering, Dongguan University of Technology, Dongguan, 523808, China.
Department of Civil and Environmental Engineering, Tokyo Institute of Technology, Meguro-ku, Tokyo, 152-8552, Japan.
Chemosphere. 2022 Jun;297:134106. doi: 10.1016/j.chemosphere.2022.134106. Epub 2022 Feb 25.
Antihypertensive propranolol (PRO) is frequently detected in surface waters and has adverse effects on aquatic organisms. In this study, its photochemical fate in surface water with the aspect of kinetics, products and toxicity were investigated employing steady-state photochemistry experiments and ecotoxicity tests. The results showed that photodegradation of PRO was enhanced in river water than that in phosphate buffer where dissolved organic matter (DOM), NO, and HCO played important roles. DOM accelerated the photodegradation mainly through generation of excited triplet-state DOM while NO played dual roles in the photodegradation. The reaction between excited triplet-state PRO and HCO can generate carbonate radical (CO) to promote the photodegradation. The second-order reaction rate constant between PRO and CO was determined to be (3.4 ± 0.8) × 10 M s. Eight photodegradation products were identified in the studied river water sample. Finally, the toxicity evaluated by Vibrio fischeri increased after photodegradation and three photodegradation products were responsible for the increasing toxicity, which was concluded from the significant correlation between toxicity parameters and quantity of the photodegradation products.
抗高血压药物普萘洛尔（PRO）经常在地表水中被检测到，并且对水生生物有不利影响。在本研究中，利用稳态光化学实验和生态毒性测试，从动力学、产物和毒性方面研究了其在地表水中的光化学归宿。结果表明，与磷酸盐缓冲液相比，PRO在河水中的光降解增强，其中溶解有机物（DOM）、NO和HCO₃⁻发挥了重要作用。DOM主要通过生成激发三线态DOM加速光降解，而NO在光降解中发挥双重作用。激发三线态PRO与HCO₃⁻之间的反应可生成碳酸根自由基（CO₃⁻）以促进光降解。PRO与CO₃⁻之间的二级反应速率常数测定为(3.4 ± 0.8) × 10⁹ M⁻¹ s⁻¹。在所研究的河水样品中鉴定出8种光降解产物。最后，通过费氏弧菌评估的毒性在光降解后增加，三种光降解产物导致了毒性增加，这是从毒性参数与光降解产物量之间的显著相关性得出的结论。
